Prehabilitation with resistance training for women with breast cancer before surgery
Prehabilitation Based on Resistance-exercise Training in Women With Breast Cancer Undergoing Neoadjuvant Therapy: From Molecular Mechanism to Clinical Benefits
This study tests if a structured resistance training program can help postmenopausal women with breast cancer improve their muscle strength and quality of life before surgery compared to those who only receive standard care.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 68 (estimated) |
| Sex | Female |
| Sponsor | Universidad de La Frontera Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 2 sites (Santiago and 1 other locations) |
| Trial ID | NCT06309290 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of prehabilitation through resistance-exercise training in postmenopausal women with breast cancer undergoing neoadjuvant therapy. The study aims to compare the outcomes of participants receiving usual care versus those engaging in a structured resistance training program over 16-20 weeks prior to surgery. The primary focus is on increasing skeletal muscle mass and improving overall physical performance and quality of life. Participants will be randomly assigned to either the prehabilitation group or the control group, with assessments conducted before and after the intervention.
Who should consider this trial
Good fit: Ideal candidates are postmenopausal women with stage I, II, or III breast cancer who are sedentary and eligible for neoadjuvant chemotherapy.
Not a fit: Patients with severe comorbidities affecting muscle metabolism or mobility, or those with previous antineoplastic treatment, may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance muscle mass and improve recovery outcomes for women undergoing treatment for breast cancer.
How similar studies have performed: Other studies have shown promising results with prehabilitation and resistance training in cancer patients, suggesting potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Postmenopausal women with breast cancer in stages I, II and III with luminal breast tumor, HER2+ or TNBC * Indication for neoadjuvant chemotherapy * Candidates for curative breast surgery * Body mass index: 18.5 \<BMI \<30 kg/m2 * Sedentary (does not perform scheduled or planned physical activity ≥ 2 times a week) * Willingness to participate in the study and follow the proposed prehabilitation scheme. Exclusion Criteria: * Present comorbidities that interact with the metabolism and mobility of the muscles of the body and that do not allow the (safe) performance of strength exercises (e.g., debilitating arthritis, all neurological disorders, paralysis, among others). * Severe or uncontrolled cardiovascular disease, cardiac ejection fraction less than 50% * Previous antineoplastic treatment * Use of nutritional supplements (leucine, glutamine, casein, whey protein, fatty acids and creatine).
Where this trial is running
Santiago and 1 other locations
- Fundación Arturo López Pérez — Santiago, Chile (Recruiting)
- Department of Rehabilitation Sciences, Faculty of Medicine, Universidad de La Frontera. Temuco, Chile — Temuco, Chile (Recruiting)
Study contacts
- Principal investigator: Gabriel N Marzuca-Nassr, PT, MSc, PhD — Universidad de La Frontera
- Study coordinator: Macarena Artigas, PT, MSc
- Email: klga.macarena.artigas@gmail.com
- Phone: 990420698
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.