Prehabilitation with resistance training for women with breast cancer before surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of prehabilitation through resistance-exercise training in postmenopausal women with breast cancer undergoing neoadjuvant therapy. The study aims to compare the outcomes of participants receiving usual care versus those engaging in a structured resistance training program over 16-20 weeks prior to surgery. The primary focus is on increasing skeletal muscle mass and improving overall physical performance and quality of life. Participants will be randomly assigned to either the prehabilitation group or the control group, with assessments conducted before and after the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Postmenopausal women with breast cancer in stages I, II and III with luminal breast tumor, HER2+ or TNBC
* Indication for neoadjuvant chemotherapy
* Candidates for curative breast surgery
* Body mass index: 18.5 \<BMI \<30 kg/m2
* Sedentary (does not perform scheduled or planned physical activity ≥ 2 times a week)
* Willingness to participate in the study and follow the proposed prehabilitation scheme.

Exclusion Criteria:

* Present comorbidities that interact with the metabolism and mobility of the muscles of the body and that do not allow the (safe) performance of strength exercises (e.g., debilitating arthritis, all neurological disorders, paralysis, among others).
* Severe or uncontrolled cardiovascular disease, cardiac ejection fraction less than 50%
* Previous antineoplastic treatment
* Use of nutritional supplements (leucine, glutamine, casein, whey protein, fatty acids and creatine).

Where it's running

• Fundación Arturo López Pérez
  Santiago, Chile Recruiting
• Department of Rehabilitation Sciences, Faculty of Medicine, Universidad de La Frontera. Temuco, Chile
  Temuco, Chile Recruiting

Study contacts

• Principal investigator: Gabriel N Marzuca-Nassr, PT, MSc, PhD — Universidad de La Frontera
• Study coordinator: Macarena Artigas, PT, MSc
• Email: klga.macarena.artigas@gmail.com
• Phone: 990420698

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Gyrotonic exercise for elders with breast cancer and Behcet disease

  We’re testing whether a gyrotonic exercise program helps older people who have both Behcet disease and breast cancer.

  Recruiting Cairo University · Giza, Dokki · NCT07929116

• PECS II vs SPSIP nerve blocks for pain after mastectomy

  This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.

  Recruiting Bursa City Hospital · Nilufer, Bursa · NCT07929090

• CG-7321: a first-in-human test in advanced solid tumors

  We’re testing CG-7321 alone and with fulvestrant to see if it’s safe and tolerable in adults with advanced solid tumors.

  Recruiting at 4 sites Phase 1 Chengdu Cynogen Bio-pharmaceutical Tech. Co., Ltd. · Fuzhou, Fujian and 3 other locations · NCT07923214

• Compare a new endoscopy-assisted breast-conserving surgery with the usual approach

  This study tests whether a new endoscopy-assisted breast-conserving technique can provide similar or better cosmetic outcomes and safety compared with conventional breast-conserving surgery in women with early breast cancer who want to preserve their breast.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou, Zhejiang and 21 other locations · NCT07920094

• Different skin care approaches to prevent skin reactions after mastectomy radiation

  This study tests three standard skin care methods to see which best prevents radiation dermatitis in people who had a mastectomy and are receiving post-mastectomy radiation therapy.

  Recruiting at 7 sites Phase 2 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT07918989

• 3D Heart Strain to Detect Early Cardiotoxicity in Cancer Therapy

  This study tests whether 3D echocardiography can detect early heart damage from cancer treatments like anthracyclines or HER2-targeted therapy better than standard 2D methods.

  Recruiting Region Skane · Lund, Skåne County · NCT07916337

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.