Prehabilitation program to improve recovery in lung cancer surgery patients
A Prehabilitation Program to Boost Postoperative Functional Capacity in Surgical Lung Cancer Patients: a Randomized Controlled Trial
This study tests whether a prehabilitation program that includes exercise and health education can help lung cancer patients recover better after surgery.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 198 (estimated) |
| Ages | 45 Years to 80 Years |
| Sex | All |
| Sponsor | The University of Hong Kong Academic / other |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT04826835 on ClinicalTrials.gov |
What this trial studies
This research evaluates a prehabilitation intervention aimed at enhancing postoperative functional capacity in patients undergoing lung resection for lung cancer. The program includes physical activity and health education to prepare patients for surgery. Functional capacity will be measured using the 6-minute walking distance test. The study targets individuals diagnosed with stage I, II, or IIIA non-small-cell lung carcinoma who are scheduled for surgery within two weeks of recruitment.
Who should consider this trial
Good fit: Ideal candidates are patients aged 45-80 with stage I, II, or IIIA non-small-cell lung carcinoma who are scheduled for lung resection and have a baseline 6-minute walking distance of 500 meters or less.
Not a fit: Patients who have engaged in at least 150 minutes of moderate aerobic activity per week in the past 3 months may not benefit from this study.
Why it matters
Potential benefit: If successful, this program could significantly improve recovery outcomes and functional capacity for lung cancer surgery patients.
How similar studies have performed: Other studies have shown positive outcomes with prehabilitation interventions in surgical patients, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients who are diagnosed of stage I, II, or IIIA Non-small-cell lung carcinoma (NSCLC) diagnosis, with or without pre-operative histologic confirmation 2. Patients scheduled to undergo lung resection surgery at least two weeks from recruitment 3. Patients with a Eastern Cooperative Oncology Group (ECOG) score of 0 or 1 at recruitment 4. Patients with no evidence of recurrent or progressive disease 5. Patients aged 45-80 years 6. Patients able to communicate in Cantonese, Mandarin, or English 7. Patients is absence of any cognitive impairment 8. Patients with a score of 6 minutes walking test (6MWT) ≤ 500 meters at baseline. \[rationale: a threshold value of 500 meters preoperative 6MWT predicts a higher risk of postoperative complications and prolonged LOS after lung resection\] 9. Engagement in less than 150 minutes of moderate aerobic activity per week in the past 3 months Exclusion Criteria: 1. Patients who had engaged in at least 150 minutes of moderate aerobic activity or 75 minutes of vigorous aerobic activity per week in the past three months 2. Presence of another concurrent, actively treated malignancy 3. Presence of chronic obstructive pulmonary disease 4. Presence of significant comorbidities that impede ability to engage in exercise, such as congestive heart failure, orthopedic disorders of the lower limbs, respiratory failure, or the need for portable oxygen therapy for activities of daily living 5. Not having a smart device to receive WhatsApp messages
Where this trial is running
Hong Kong
- Queen Mary Hospital — Hong Kong, Hong Kong (Recruiting)
Study contacts
- Study coordinator: Chia-chin Lin, PhD
- Email: cclin@hku.hk
- Phone: 39176614
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.