Preeclampsia and normal pregnancy: retinal microcirculation using OCTA

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study examines retinal and choroidal microcirculation in pregnant individuals, comparing those with preeclampsia to healthy controls. Participants undergo Optical Coherence Tomography Angiography (OCTA) imaging to assess microvascular changes in the retina. The project explores whether ocular microvascular patterns reflect systemic endothelial dysfunction seen in preeclampsia. Inclusion requires women aged 18-45 with singleton pregnancies and no major ocular or systemic comorbidities. Data collection focuses on imaging quality, timing after 20 weeks gestation, and clinical concordance with maternal health status.

Why it matters

Who can join: the full rules

Inclusion Criteria:

\-

Female participants aged 18-45 years.

Willingness to participate in the study and provision of written informed consent.

Absence of ocular media opacities that could interfere with Optical Coherence Tomography (OCT) or Optical Coherence Tomography Angiography (OCTA) imaging (e.g., dense cataract or vitreous hemorrhage).

No history of previous ocular surgery.

No high refractive error (refractive error greater than ±6 diopters).

Singleton pregnancy for participants in the pregnant groups.

Preeclampsia group:

Diagnosis of preeclampsia after the 20th week of gestation according to established clinical criteria.

No history of chronic hypertension, diabetes mellitus, chronic kidney disease, retinopathy or other ocular diseases, systemic vasculitis, or collagen vascular disease prior to pregnancy.

Healthy pregnant control group:

Healthy pregnancy without preeclampsia or hypertensive disorders of pregnancy.

No history of hypertension, diabetes mellitus, chronic kidney disease, retinopathy or other ocular diseases, systemic vasculitis, or collagen vascular disease.

Healthy non-pregnant control group:

Healthy non-pregnant women without a history of hypertension, diabetes mellitus, chronic kidney disease, retinopathy or other ocular diseases, systemic vasculitis, or collagen vascular disease.

Exclusion Criteria:

\- History of chronic hypertension prior to pregnancy.

Diagnosis of diabetes mellitus (DM) or gestational diabetes mellitus (GDM).

Presence of chronic kidney disease.

History of retinopathy or other ocular diseases, including glaucoma, uveitis, retinal detachment, or macular pathology.

Multiple pregnancy (twin pregnancy or higher-order gestation).

History of systemic vasculitis or collagen vascular disease.

History of previous ocular surgery.

Presence of high refractive error (greater than ±6 diopters).

Poor image quality preventing reliable analysis of Optical Coherence Tomography (OCT) or Optical Coherence Tomography Angiography (OCTA) images.

Failure to provide written informed consent.

Age below 18 years or above 45 years.

Where it's running

• Muğla Sıtkı Koçman University Training and Research Hospital
  Muğla, Menteşe, Turkey (Türkiye) Recruiting

Study contacts

• Study coordinator: beril kanat, Dr
• Email: berilneslik@gmail.com
• Phone: +905334791167

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• MH-Rx: Check-in on You, Your Medication, and Your Blood Pressure for Pregnant People

  This trial tests whether adding virtual social-support and medication management to remote blood pressure monitoring helps pregnant people with chronic or gestational hypertension.

  Recruiting Texas Southern University · Houston, Texas · NCT07842341

• Maternal insulin and fat metabolism in pregnancies at risk for preeclampsia and gestational diabetes

  This project will try to see if insulin resistance and how the body burns fats early in pregnancy predict later preeclampsia or gestational diabetes in people at higher risk.

  Recruiting University of Tennessee Graduate School of Medicine · Knoxville, Tennessee · NCT07565727

• Behavioral toolkit to help pregnant women manage gestational diabetes and pregnancy-related high blood pressure.

  This program will test whether a structured behavioral toolkit helps pregnant women with both gestational diabetes and pregnancy-induced high blood pressure better control their blood sugar and blood pressure.

  Recruiting at 2 sites University of the Punjab · Lahore, Punjab Province and 1 other locations · NCT07551011

• Origins, features, and effects of preeclampsia on mother and baby

  This project will follow pregnant women diagnosed with preeclampsia through late pregnancy, delivery, and early postpartum to collect clinical data and biological samples to see how preeclampsia affects mothers and their babies.

  Recruiting Medical University of Graz · Graz · NCT07513558

• National first-trimester screening program to prevent preeclampsia in Denmark

  This program will try a new first-trimester screening for pregnant women with a single pregnancy in Denmark to find those at high risk of preeclampsia and offer early prevention such as low-dose aspirin.

  Recruiting at 3 sites Copenhagen University Hospital at Herlev · Aarhus and 2 other locations · NCT07485140

• Blood protein markers and heart changes in pregnant women with preeclampsia

  This study tests whether blood proteins can reveal early heart changes in pregnant women with preeclampsia and uses heart ultrasound to see how the heart changes during pregnancy.

  Recruiting Washington University School of Medicine · Abuja · NCT07463898

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.