Predictive brain flexibility in autistic and non-autistic people

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study uses fMRI to compare neural activity related to predictive brain mechanisms during high-level cognitive flexibility tasks that involve social and non-social stimuli. It includes autistic and non-autistic participants of different sexes to see if there are sex-related neurofunctional differences. The researchers aim to determine whether predictability and social context influence cognitive flexibility differently in autism. The protocol examines behavioral performance and brain networks during social vs non-social, predictable vs unpredictable task conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

For non autistic individuals

* Affiliation with social security scheme.
* Registration in the national database of individuals willing to participate in research involving human subjects.
* Absence of contraindications for MRI.
* Signed informed consent before any study-related procedure.
* Visual acuity allowing normal perception of stimuli or corrected vision.
* Autism Quotient (AQ) (Baron-Cohen et al., 2001) \< 32.

For autistic individuals:

* Affiliation with social security scheme.
* Absence of contraindications for MRI.
* Signed informed consent before any study-related procedure.
* Visual acuity allowing normal perception of stimuli or corrected vision.
* Diagnosis of autism established by a competent professional based on DSM/ICD criteria.

Exclusion Criteria:

* Any subject with a vascular stent implanted less than 6 weeks before the examination.
* Any subject with implanted biomedical material deemed "unsafe" or "not safe" in the list: http://www.mrisafety.com/TheList\_search.asp.
* Any acquisition procedure not meeting the conditions required for "conditional" use in subjects with implanted biomedical material classified as "conditional" in the list: http://www.mrisafety.com/TheList\_search.asp.
* Any subject with biomedical material such as a cardiac, neuronal, or sensory stimulator (cochlear implant due to the risk of demagnetization, heating, electrode, and artifacts) or a ventricular shunt valve without medical and paramedical supervision trained in MRI performance in these subjects.
* Intraocular or intracranial ferromagnetic foreign body near nerve structures (risk of displacement and complications such as ocular or cerebral lesions).
* Claustrophobia - Psychiatric or neurological conditions other than those specified.
* Existence of a severe general health condition incompatible with the study: cardiac, respiratory, hematological, renal, hepatic, or cancerous.
* Alcohol ingestion before the examination.
* Persons covered by articles L1121-5 to L1121-8 of the Public Health Code (pregnant or breastfeeding women, minors or adults under legal protection, individuals under administrative or judicial surveillance).
* Visual impairments.
* Intellectual disability.
* Inability to understand research instructions or provide informed consent.

Where it's running

• CHU Grenoble Alpes_DRCI_Pavillon Dauphiné_CS
  Grenoble, France Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.