Predicting unstable carotid plaques using radiomics and biomechanics

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will integrate radiomic features from imaging with biomechanical data to predict plaque instability in patients with significant carotid atherosclerosis. The study uses prospective–retrospective data and biological samples to develop a predictive model. The goal is to identify high-risk plaques in asymptomatic patients before any stroke occurs, complementing existing risk stratification methods. Eligible participants are adults with stenosis of 70% or more who are planned for carotid endarterectomy and have preoperative imaging. This work could guide earlier, targeted interventions and reduce stroke risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients ≥ 18 years of age;
* Affected by significant carotid atherosclerosis, whether symptomatic or asymptomatic (stenosis ≥ 70% according to ECST criteria).
* Candidates for carotid ATE surgery. The criteria provided by the SICVE and ESVS guidelines will be followed for indications for surgery;
* Preoperative imaging available;

Exclusion Criteria:

* Patients who have undergone previous carotid endarterectomy (ipsilateral to the affected side);
* Patients who have undergone previous neck surgery involving cervical lymph node dissection;
* Patients who have undergone previous neck radiation therapy;
* Lack of preoperative imaging;
* Patients unable to sign informed consent.

Where it's running

• Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
  Milan, Italy Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using IMPROVE to guide carotid revascularisation decisions

  This trial tests whether using the IMPROVE MRI-based score to select patients for carotid revascularisation is as good as standard care based mainly on stenosis degree, among people who have had a recent stroke or TIA due to carotid disease.

  Recruiting Maastricht University Medical Center · Arnhem, Gelderland and 9 other locations · NCT07556887

• How menopause and HIV together affect cardiovascular disease risk in women.

  This study will see if menopause combined with HIV raises heart disease risk in women with HIV by examining risk factors, inflammation, body composition, and whole-body MRI.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07284082

• PET/MRI with [18F]AlF-NOTA-octreotide to image inflammation in carotid artery plaque

  This will test whether [18F]AlF-OC PET/MRI can measure inflammation in carotid plaques and help predict recurrent stroke or TIA in people who recently had a carotid-territory stroke or high-risk TIA with at least 30% carotid stenosis.

  Recruiting Phase 2 Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT07104487

• Residual and recurrent carotid narrowing after endarterectomy with primary closure

  The study will test how often and when carotid narrowing comes back after elective carotid endarterectomy with primary closure in adults.

  Recruiting Charles University, Czech Republic · Prague · NCT07057297

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.