Predicting thinking problems and trying dual-task walking to boost cognition in people with colorectal cancer
Developing Risk Prediction Model of Mild Cognitive Impairment in Patients With Colorectal Cancer From Active Treatment to Survivor and Testing the Effect of Dual Task Walking on Improving Cognitive Function
This project will test whether adding simple thinking tasks to walking can help improve memory, attention, and executive function in people newly diagnosed with stage I–III colorectal cancer while also building a model to predict who is most at risk for cancer-related cognitive problems.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 355 (estimated) |
| Ages | 40 Years to 75 Years |
| Sex | All |
| Sponsor | National Taiwan University Hospital Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Taipei) |
| Trial ID | NCT04490733 on ClinicalTrials.gov |
What this trial studies
The study first uses cross-sectional and longitudinal assessments to measure subjective and objective cognitive function across different treatment stages (surgery, chemotherapy) and to identify factors linked with cancer-induced cognitive impairment. Researchers will develop a risk prediction model for mild cognitive impairment related to colorectal cancer treatments and use qualitative interviews to understand patients' experiences and coping. In a second phase they will create a dual-task walking training program and test its effects on memory, attention, and executive function in a randomized controlled trial. Outcome measures combine cognitive tests and patient-reported cognitive symptoms collected at the hospital over the study period.
Who should consider this trial
Good fit: Adults newly diagnosed with stage I–III colorectal cancer who have no other active cancers or recurrence and who can safely walk and participate in the training are ideal candidates.
Not a fit: Patients with metastatic (stage IV) disease, cancer recurrence, other active cancers, severe pre-existing cognitive impairment, or who cannot walk safely are unlikely to benefit from this walking-based intervention.
Why it matters
Potential benefit: If successful, the program could help some colorectal cancer patients improve memory, attention, and everyday thinking and help clinicians identify patients at highest risk for cognitive decline.
How similar studies have performed: Exercise and dual-task interventions have shown promise for improving cognition in older adults and some cancer groups, but applying a dual-task walking program specifically to colorectal cancer-related cognitive problems is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with newly diagnosed stage I to III colorectal cancer. Exclusion Criteria: * Patients with cancer other than colorectal cancer or have cancer recurrence.
Where this trial is running
Taipei
- National Taiwan University — Taipei, Taiwan (Recruiting)
Study contacts
- Study coordinator: Shiow-Ching Shun, PHD
- Email: scshun@ntu.edu.tw
- Phone: 886-911-268-998
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.