Predicting thinking and memory problems after heart surgery in older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective cohort of patients aged 65 and older who undergo cardiac surgery with cardiopulmonary bypass, with blood samples and functional MRI collected at baseline and key postoperative time points. Cognitive status will be measured with standard scales (MMSE and MoCA) before and after surgery. Researchers will search for peripheral blood protein biomarkers, examine relationships between fMRI features and postoperative cognitive decline, and combine these data to build an early prediction model. The goal is to use multimodal data to improve perioperative risk stratification and guide interventions to reduce postoperative cognitive dysfunction.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects aged ≥65 years, with no gender restriction. Patients meet the indications for cardiac surgery (cardiac surgery with cardiopulmonary bypass).

Normal liver and renal function during the screening period. No evidence of active infection during the screening period. Able to cooperate in answering questions related to the MMSE and MoCA cognitive scales during the screening period.

Have signed the informed consent form.

Exclusion Criteria:

* The investigator considers that the subject has conditions that may interfere with the study results.

Subjects with evidence of active liver disease (liver function test results: ALT or AST ≥ 2 times the upper limit of normal \[ULN\]) or chronic active hepatitis B or C within 1 month.

Active systemic infection requiring antibacterial drugs within 1 week before surgery.

Preoperative low MMSE score (illiterate: \<17 points; primary school education: \<20 points; middle school education or above: \<24 points).

Patients with one or more of the following diseases:

Classified as obese (body mass index ≥ 30 kg/m²); Uncontrolled hypertension (defined as systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 100 mmHg); History of organ transplantation, including corneal transplantation; Any clinically significant uncontrolled respiratory disease, including but not limited to chronic obstructive pulmonary disease, asthma, bronchiectasis, or pleural effusion; Previously diagnosed or suspected demyelinating diseases, including multiple sclerosis, Guillain-Barré syndrome, etc.; Use of any glucocorticoids or immunosuppressive agents; Any disease that significantly affects the nervous system. Participation in other clinical trials.

Where it's running

• Shanghai Geriatric Medical Center
  Shanghai, China Recruiting

Study contacts

• Study coordinator: Hao Fang
• Email: drfanghao@163.com
• Phone: 02164175590

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Early cognitive changes after same-day hip or knee replacement

  This study tests whether older adults (65 or older, 70 per description) who have same-day discharge after hip or knee replacement show changes in cognitive test performance from before surgery to the first day after surgery.

  Recruiting Odense University Hospital · Svendborg · NCT07598552

• How ciprofol behaves and affects older adults having limb surgery under general anesthesia

  This study tests whether ciprofol provides safe and effective anesthesia for older adults having elective limb surgery by measuring drug levels and clinical responses.

  Recruiting Shanghai Geriatric Medical Center · Shanghai · NCT07301242

• Delayed arm-cuff conditioning to reduce lung complications after non-cardiac, non-thoracic surgery in older adults

  This study will test whether inflating a blood-pressure cuff on the arm in short cycles about 24 hours before surgery can lower the risk of lung problems after surgery in people aged 65 and older.

  Recruiting Shanghai Geriatric Medical Center · Shanghai · NCT07208500

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.