Predicting the origin of outflow tract ventricular arrhythmias using a hybrid score
A Hybrid Score to Predict the Origin of Outflow Tract Ventricular Arrhythmias in Patients with Intraventricular Conduction Disorders or Paced Rhythm
This study is testing a new scoring system to see if it can help find the source of certain heart rhythm problems in patients with wide QRS complexes, aiming to improve treatment success and safety.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Centro Medico Teknon Academic / other |
| Locations | 6 sites (Brussels, Belgium and 5 other locations) |
| Trial ID | NCT06602635 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the effectiveness of a hybrid scoring system that combines clinical and ECG data to predict the site of origin for outflow tract ventricular arrhythmias (OTVA) in patients with wide basal QRS complexes. The study includes patients with structural heart disease and those with cardiac implantable electronic devices, which are often excluded from similar studies. By accurately identifying the origin of OTVA, the study seeks to improve the success of catheter ablation procedures and reduce associated risks. Participants must have a QRS width greater than 110 ms and be willing to provide informed consent.
Who should consider this trial
Good fit: Ideal candidates for this study are patients experiencing ventricular arrhythmias with a morphology indicating an outflow tract origin and a wide basal QRS complex.
Not a fit: Patients who have had unsuccessful catheter ablation procedures or infrequent arrhythmias requiring ablation guided by pacemapping may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the accuracy of catheter ablation procedures for patients with outflow tract ventricular arrhythmias, leading to better treatment outcomes.
How similar studies have performed: While similar studies have focused on predicting OTVA origins, this study's inclusion of patients with structural heart disease and cardiac devices represents a novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * ventricular arrhythmia with a morphology indicating an outflow tract origin and a wide basal QRS complex * a QRS width greater than 110 ms was considered wide * willing and capable of providing written informed consent to the study Exclusion Criteria: * catether ablation procedure was unsuccessful * infrequent arrhythmia requiring ablation guided by pacemapping.
Where this trial is running
Brussels, Belgium and 5 other locations
- Vrije Universiteit Brussel — Brussels, Belgium, Belgium (Recruiting)
- Maria Cecilia Hospital — Cotignola, Italy, Italy (Recruiting)
- Niguarda Ca Granda Hospital — Milan, Italy, Italy (Recruiting)
- Cisanello University Hospital (Pisa, Italy) — Pisa, Italy, Italy (Recruiting)
- Teknon Medical Center — Barcelona, Spain, Spain (Recruiting)
- Hospital Universitario Puerta del Mar — Cadiz, Spain, Spain (Recruiting)
Study contacts
- Study coordinator: Antonio Berruezo, MD, PhD
- Email: antonio.berruezo@quironsalud.es
- Phone: 3384090290
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.