Predicting rheumatoid arthritis flares using patient data and blood markers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows adults with rheumatoid arthritis who are in remission or low disease activity to see if specific patient characteristics and inexpensive blood markers can predict upcoming flares. Participants are monitored every three months for 17 months, with data collected on clinical status, radiographic damage, and blood-derived indices such as NLR, PLR, SII, SIRI, and PIV. Flare is defined by standard DAS28 criteria, and results could help clinicians tailor treatment timing to prevent worsening symptoms and joint damage. The study analyzes how disease duration, time to remission, medication adherence, baseline radiographic damage, and inflammatory biomarkers relate to flare risk. Interventions involve regular clinical and laboratory monitoring, without experimental treatments.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: patients \>18 years old.
* Patients with rheumatoid arthritis diagnosed according to the 2010 American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology Classification Criteria for RA.
* Clinical remission or low disease activity according to the disease activity score in 28 joints (DAS28).

Exclusion Criteria:

* Age \< 18 years.
* Any autoimmune disease other than Rheumatoid arthritis. Severe infection, pregnancy, and malignancy.

Where it's running

• Rheumatology and Rehabilitation Department, Faculty of Medicine, Sohag University
  Sohag, Sohag Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Esraa Mohamed Mahmoud Sayed
• Email: esraamahmoud@med.sohag.edu.eg
• Phone: +2 01016090864

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.