Predicting outcomes for comatose patients after cardiac arrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the prognosis of comatose patients following cardiac arrest in the intensive care unit using a multimodal approach. It combines clinical examinations, serum biomarkers, imaging, and electrophysiological tests, including auditory evoked potentials (AEP). A novel algorithm developed from AEP signals generates a probability map to classify patients' neurological prognosis as either good or bad. The goal is to apply this algorithm to a large cohort of patients to improve the accuracy of prognosis predictions at three months post-event.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age above18 years old
* Patient affiliated to a French Heath Care Insurance
* Admitted in the intensive care unit (ICU) for coma post extra- or intra-hospital cardiac arrest (CA) with shockable or non-shockable rhythm
* Persistent coma on day 3 after post CA, defined by the inability to respond to a verbal command in an appropriate manner (motor Glasgow components ≤ 3) and at the time of neurophysiological recordings (D3-D7 ± week -end).

Exclusion Criteria:

* Decision to limit resuscitation therapies taken by the resuscitation team
* Inability to perform the auditory evoked potentials (AEP) (deafness, skin lesion or any condition preventing to record AEP).
* Opposition by the trusted person or by the patient once he/she wakes up

Where it's running

• APHP Avicenne Hospital - Réanimation médico-chirurgicale
  Bobigny, France Recruiting
• APHP Laribosière Hospital - Service de Réanimation Médical et Toxicologique
  Paris, France Recruiting
• APHP Cochin Hospital - médecine intensive-réanimation
  Paris, France Recruiting
• APHP HEGP hospital - Réanimation médicale
  Paris, France Recruiting
• APHP Bichat Hospital -Médecine intensive - réanimation infectieuse
  Paris, France Recruiting
• Delafontaine Hospital - médecine intensive-réanimation
  Saint-Denis, France Recruiting

Study contacts

• Study coordinator: Nathalie KUBIS, Md, PhD
• Email: nathalie.kubis@aphp.fr
• Phone: +33(0)149958324

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.