Clinical trial Recruiting at 1 site Observational Ages 18 and up

Predicting neuromuscular block during anesthesia

Official title: Predictive Modelling of the Intraoperative Train-of-Four (TOF) Ratio

Run by Universitair Ziekenhuis Brussel · NCT04518761 · Data updated 2026-11-12

This study is trying to see if a new way of measuring muscle response during anesthesia can help doctors better manage the use of a muscle relaxant in adults having non-heart surgery.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment200 (estimated)
SponsorUniversitair Ziekenhuis Brussel
Academic / other
Locations2 sites (Jette, Brussels Capital and 1 other locations)
StatusRecruiting
StartedJuly 1, 2020
Main results expectedDecember 31, 2026
Study endsDecember 31, 2026
Registry record updatedApril 29, 2026
Trial IDNCT04518761 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adult patients aged 18 and older undergoing noncardiac surgery with general anesthesia requiring Rocuronium.

Probably not a fit

Patients with known neuromuscular diseases or those receiving different neuromuscular blocking agents during the same procedure may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop a predictive model for the Train-of-Four (TOF) ratio during anesthesia by analyzing neuromuscular monitoring data. It focuses on adult patients undergoing noncardiac surgery who receive general anesthesia with the neuromuscular blocking agent Rocuronium. The study utilizes electrical stimuli applied to the ulnar nerve to measure the motor response of the thumb, which is then analyzed to determine the effectiveness of neuromuscular blockade. The goal is to enhance the evidence-based use of neuromuscular blocking agents in clinical practice.

Why it matters

Potential benefit: If successful, this study could improve the safety and effectiveness of neuromuscular blocking agents during surgery.

How similar studies have gone: While the approach of using TOF monitoring is established, the specific predictive modeling aspect of this study may offer novel insights.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Adult patients (18 years old and above) receiving General Anesthesia for noncardiac surgery requiring the use of a neuromuscular blocking agent.
* Administration of General Anesthesia by means of Total Intravenous Anesthesia technique.
* Use of Rocuronium as a neuromuscular blocking agent.

Exclusion Criteria:

* Use of different types of neuromuscular blocking agents for the same patient within the same surgical procedure
* Known Neuromuscular diseases/syndromes judged to condition accurate neuromuscular monitoring.

Where it's running

  • UZ Brussel
    Jette, Brussels Capital, Belgium
    Recruiting
  • AZ Sint Jan
    Bruges, Wv, Belgium
    Not yet recruiting

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.