Predicting neuromuscular block during anesthesia
Predictive Modelling of the Intraoperative Train-of-Four (TOF) Ratio
This study is trying to see if a new way of measuring muscle response during anesthesia can help doctors better manage the use of a muscle relaxant in adults having non-heart surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Universitair Ziekenhuis Brussel Academic / other |
| Locations | 2 sites (Jette, Brussels Capital and 1 other locations) |
| Trial ID | NCT04518761 on ClinicalTrials.gov |
What this trial studies
This observational study aims to develop a predictive model for the Train-of-Four (TOF) ratio during anesthesia by analyzing neuromuscular monitoring data. It focuses on adult patients undergoing noncardiac surgery who receive general anesthesia with the neuromuscular blocking agent Rocuronium. The study utilizes electrical stimuli applied to the ulnar nerve to measure the motor response of the thumb, which is then analyzed to determine the effectiveness of neuromuscular blockade. The goal is to enhance the evidence-based use of neuromuscular blocking agents in clinical practice.
Who should consider this trial
Good fit: Ideal candidates are adult patients aged 18 and older undergoing noncardiac surgery with general anesthesia requiring Rocuronium.
Not a fit: Patients with known neuromuscular diseases or those receiving different neuromuscular blocking agents during the same procedure may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the safety and effectiveness of neuromuscular blocking agents during surgery.
How similar studies have performed: While the approach of using TOF monitoring is established, the specific predictive modeling aspect of this study may offer novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (18 years old and above) receiving General Anesthesia for noncardiac surgery requiring the use of a neuromuscular blocking agent. * Administration of General Anesthesia by means of Total Intravenous Anesthesia technique. * Use of Rocuronium as a neuromuscular blocking agent. Exclusion Criteria: * Use of different types of neuromuscular blocking agents for the same patient within the same surgical procedure * Known Neuromuscular diseases/syndromes judged to condition accurate neuromuscular monitoring.
Where this trial is running
Jette, Brussels Capital and 1 other locations
- UZ Brussel — Jette, Brussels Capital, Belgium (Recruiting)
- AZ Sint Jan — Bruges, Wv, Belgium (Not_yet_recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.