Predicting Low Cardiac Output in Children After Heart Surgery Using CO2-Derived Parameters
Official title: Performance of CO2-derived Parameters in Predicting Low Cardiac Output Syndrome in Children After Cardiac Surgery With Cardiopulmonary Bypass
Run by University Hospital, Lille · NCT07770386 · Data updated 2026-11-12
This study tests whether CO2-derived measures can help identify low cardiac output in children after congenital heart surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | Any age to 17 Years |
| Sex | All |
| Enrollment | 306 (estimated) |
| Sponsor | University Hospital, Lille Academic / other |
| Locations | 1 site (Lille) |
| Status | Recruiting |
| Started | June 27, 2026 |
| Main results expected | June 27, 2029 |
| Study ends | July 2029 |
| Registry record updated | September 9, 2026 |
| Trial ID | NCT07770386 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Children under 18 who have undergone congenital heart surgery with extracorporeal circulation and have both central venous and arterial catheters, treated in the Lille pediatric ICU.
✕Probably not a fit
Patients without postoperative LCOS or without usable CO2-derived measurements may not experience a direct benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study examines whether venous-to-arterial CO2 differences and related ratios can predict low cardiac output syndrome in pediatric patients after extracorporeal circulation. It focuses on children under 18 who have undergone cardiac surgery and are treated in a pediatric ICU, using central and arterial catheter measurements. The goal is to determine thresholds that may indicate LCOS in this surgical population, which could inform clinical decisions and management. No interventions are assigned; the study analyzes data collected during routine care. Results could help improve postoperative monitoring and potentially reduce complications and length of stay.
Why it matters
Potential benefit: If successful, physicians may detect LCOS earlier and tailor therapies to improve recovery after pediatric heart surgery.
How similar studies have gone: CO2-derived parameters have shown predictive value in adult postoperative settings, but their utility in pediatric cardiac surgery remains to be clearly established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Children under the age of 18 * Post-operative cardiac surgery * Surgery with extracorporeal circulation * With a central venous catheter and an arterial catheter * Admitted to the pediatric intensive care unit at Lille University Hospital * Patient covered by the social security system (or equivalent) Exclusion Criteria: * Pre-existing renal insufficiency prior to cardiac surgery * Opposition from the holder of parental authority * Difficulty understanding or communicating, making it impossible to inform the holder of parental authority * Patient under legal protection (guardianship, curatorship, legal safeguard) * Malposition of the central venous catheter * Malposition of the arterial catheter * Biological samples that cannot be interpreted
Where it's running
-
CHU Lille
Lille, France Recruiting
Study contacts
- Study coordinator: Celine CLAIRET-LESPINASSE
- Email: celine.clairet@chu-lille.fr
- Phone: +33 3204441145
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.