Predicting how coronary artery disease progresses in adults 45 and younger

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a large, multicenter observational effort across China enrolling about 10,000 participants aged 18–45 who undergo coronary CT. At enrollment the project collects basic health information, cardiovascular risk factors, blood test results, medication use, lifestyle habits, and optional genetic data for some participants. Participants will be asked to return for follow-up coronary CT scans after several years to measure changes in plaque and disease progression. The collected clinical and imaging data will be used to identify factors linked to progression and to build models that estimate future plaque progression and cardiovascular event risk.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 18 and 45 years at the time of enrollment.
2. Presence of symptoms suggestive of coronary artery disease and completion of coronary computed tomography (CT) examination.
3. Ability and willingness to provide written informed consent and to participate in follow-up assessments.

Exclusion Criteria:

1. Inability or unwillingness to complete follow-up assessments.
2. Inability to provide written informed consent.
3. History of coronary revascularization, including percutaneous coronary intervention or coronary artery bypass grafting.
4. Poor-quality coronary computed tomography images that are inadequate for reliable plaque assessment.
5. Presence of severe systemic disease with limited life expectancy that may interfere with study follow-up.
6. Pregnant or breastfeeding women.
7. Participation in another clinical study that may interfere with the outcomes of this study.

Where it's running

• FuWai hospital
  Beijing, China Recruiting

Study contacts

• Study coordinator: Zhihui Hou, MD, PhD
• Email: konglingyihui@126.com
• Phone: +86 15011451210

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.