Predicting failure of non-invasive ventilatory support in patients with respiratory failure
PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure: the PREVISION Study
This study is testing if certain non-invasive tools can help predict when patients with breathing problems might need more help while using high flow nasal cannulas or non-invasive ventilation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Unity Health Toronto Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Toronto, Ontario) |
| Trial ID | NCT06716463 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate non-invasive tools, such as electrical impedance tomography (EIT) and ultrasound of respiratory muscles, to predict the risk of failure in patients using high flow nasal cannula (HFNC) or non-invasive ventilation (NIV). It will enroll patients who are experiencing acute hypoxemic respiratory failure or are at risk of reintubation. The study will monitor lung mechanics and muscle activity while patients are on HFNC or NIV, collecting various physiological parameters and patient characteristics. The goal is to determine if abnormal regional ventilation can predict the failure of these non-invasive support methods.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are using HFNC or NIV in a hospital setting.
Not a fit: Patients with chronic CO2 retention, neuromuscular disorders, or those requiring home NIV may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved patient outcomes by identifying those at risk of ventilatory support failure earlier.
How similar studies have performed: Other studies utilizing non-invasive monitoring techniques have shown promise, but this specific approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age of ≥ 18 years * Using NIV or HFNC anywhere in the hospital Exclusion Criteria: * Chronic CO2 retention * Neuromuscular disorder * Requiring home NIV (CPAP or BIPAP) * Tracheostomy * Contraindication to EIT placement: pacemaker/defibrillator implantation, burns at the area of EIT placement
Where this trial is running
Toronto, Ontario
- St. Michael's Hospital — Toronto, Ontario, Canada (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.