Predicting cardiovascular risks in women with preeclampsia
Cardiac Biomarkers in Preeclampsia: Prediction of Disease and the Risk of Future Cardiovascular Events in Survivors
This study is testing if certain blood markers can help predict heart risks for women who have had preeclampsia during and after pregnancy.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 263 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | Female |
| Sponsor | Babcock University Academic / other |
| Locations | 1 site (Sagamu, Ogun) |
| Trial ID | NCT04468763 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify cardiac biomarkers that can predict preeclampsia early in pregnancy and assess the risk of future cardiovascular events in women who have survived preeclampsia. Participants will be recruited at three stages: the first trimester, the second half of pregnancy, and the postpartum period. The study will analyze serum levels of various biomarkers, including fibrinogen and triglycerides, alongside genetic studies to determine their association with cardiovascular risks. The findings could help in early detection and preventive care for women at risk of cardiovascular diseases post-preeclampsia.
Who should consider this trial
Good fit: Ideal candidates include healthy pregnant women under 20 weeks gestation, women diagnosed with preeclampsia between 20-41 weeks, and women less than one year postpartum with a history of preeclampsia or eclampsia.
Not a fit: Patients with chronic hypertension, cardiac or renal disease, diabetes mellitus, or connective tissue disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved screening and preventive strategies for cardiovascular diseases in women who have experienced preeclampsia.
How similar studies have performed: While there have been studies exploring cardiovascular risks associated with preeclampsia, this specific approach using cardiac and genetic biomarkers is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy pregnant women at gestational age less than 20 weeks * Women with diagnosis of preeclampsia at gestational age 20-41 weeks * Healthy pregnant women without preeclampsia at gestational age 20-41 weeks * Women less than one year postpartum with history of preeclampsia or eclampsia in index pregnancy * Healthy women less than 1 year postpartum with no previous history of preeclampsia or eclampsia Exclusion Criteria: * History of chronic hypertension or hypertension before pregnancy * Patients with cardiac disease * Patients with renal disease * Patients with diabetes mellitus * Patients with connective tissue disorders
Where this trial is running
Sagamu, Ogun
- Babcock University Teaching Hospital — Sagamu, Ogun, Nigeria (Recruiting)
Study contacts
- Study coordinator: Dr
- Email: imaralujohn@yahoo.co.uk
- Phone: +2348067857419
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.