Predicting brain-related causes of vertigo, dizziness, and unsteadiness in the emergency department
Official title: Lost in the Labyrinth: Predicting Central Neurological Causes of Vertigo Dizziness and Unsteadiness in the Emergency Department. A Multicentre Cross-sectional Observational Study
Run by Fondazione IRCCS Policlinico San Matteo di Pavia · NCT07287891 · Data updated 2026-11-12
This research will test whether a bedside exam algorithm used by emergency doctors can tell if an adult's vertigo, dizziness, or unsteadiness is caused by a brain problem.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 825 (estimated) |
| Sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia Academic / other |
| Locations | 1 site (Pavia, Pavia) |
| Status | Recruiting |
| Started | January 26, 2024 |
| Main results expected | February 26, 2027 |
| Study ends | February 26, 2027 |
| Registry record updated | December 17, 2025 |
| Trial ID | NCT07287891 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older who present to the ED with vertigo, dizziness, or unsteadiness and can give informed consent, without dementia or unrelated bedridden status, are ideal candidates.
✕Probably not a fit
Patients with clear focal neurological deficits or suspected stroke at triage, people with dementia, bedridden patients for other reasons, and children are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a multicentre cross-sectional observational study enrolling adults who present to the emergency department with vertigo, dizziness, or unsteadiness. Emergency physicians will perform a standardized bedside examination algorithm and their findings will be recorded. Results will be compared to the clinical reference standard (including imaging and specialist diagnosis) to calculate sensitivity, specificity, and predictors of a central cause. The study excludes patients with dementia, bedridden status for unrelated reasons, or clear neurological deficits suggesting stroke at triage.
Why it matters
Potential benefit: If successful, the algorithm could reduce misdiagnosis, lower unnecessary neuroimaging, shorten ED stays, and cut healthcare costs.
How similar studies have gone: Related bedside algorithms such as HINTS have shown high accuracy in expert hands but have variable validation in general emergency department settings, so prior results are promising but inconsistent.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients presenting at the ED with vertigo, dizziness or unsteadiness * \>= 18 years of age * Patients able to give their consent Exclusion Criteria: * Patients with dementia * Bedridden patients (for causes other than the current symptoms) * Patients with obvious neurological findings presenting with vertigo but with suspected stroke at triage
Where it's running
-
SC Pronto Soccorso e Medicina d'Urgenza, Fondazione IRCCS Policlinico San Matteo
Pavia, Pavia, Italy Recruiting
Study contacts
- Study coordinator: Marco Bonzano, MD
- Email: m.bonzano@smatteo.pv.it
- Phone: +390382502039
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.