Predicting aortic dilatation and rupture using advanced MRI techniques
Prediction of Aortic Dilation and Rupture in Different Predisposing Pathologies A Prospective Clinical Study
This study is trying to see if advanced MRI techniques can help predict which patients with a dilated aorta are at risk for serious problems like rupture, so they can get the right follow-up care.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 170 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Kuopio University Hospital Academic / other |
| Locations | 1 site (Kuopio) |
| Trial ID | NCT05065996 on ClinicalTrials.gov |
What this trial studies
This observational study aims to identify prognostic imaging parameters using 4D flow MRI to predict aortic dilatation and rupture in patients. It consists of three subtrials: the first focuses on identifying flow parameters characteristic of a dilated aorta, the second tests these parameters in clinical imaging follow-ups, and the third investigates the molecular pathology and genetics of the aorta in at-risk patients. The goal is to improve patient management by identifying those who require more intensive imaging follow-up.
Who should consider this trial
Good fit: Ideal candidates include patients with aortic dilatation who are scheduled for imaging follow-up at Kuopio University Hospital.
Not a fit: Patients who lack cooperation or have contraindications to MRI will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better risk stratification and management of patients at high risk for aortic rupture.
How similar studies have performed: While there is emerging data on the use of 4D flow MRI, this specific approach to predicting aortic dilatation and rupture is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * aortic dilatation * scheduled for imaging follow up in Kuopio University Hospital * written informed concent Exclusion Criteria: * lack of co-operation * contraindications to MRI
Where this trial is running
Kuopio
- Kuopio University Hospital — Kuopio, Finland (Recruiting)
Study contacts
- Principal investigator: Marja Hedman, Prof — Kuopio University Hospital
- Study coordinator: Saara Sillanmäki, PhD
- Email: saara.sillanmaki@kuh.fi
- Phone: +358456334855
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.