Precision exercise program to help sepsis survivors improve their fitness

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical research focuses on a 12-week precision exercise training intervention aimed at enhancing exercise tolerance in survivors of sepsis. Participants will engage in individualized, nonlinear periodized strength and aerobic exercise training three times a week, while a control group will receive usual care and lifestyle advice. The study will assess the efficacy of this tailored exercise program by comparing the exercise group's performance on constant load exercise tests to that of the control group. Additionally, participants will complete questionnaires and provide blood samples to evaluate patient-reported outcomes and immune function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Signed informed consent
* At least 19 years of age
* ≥60 days prior to study enrollment, known or suspected infection that includes at least two of the following clinical criteria that together constitute a new bedside clinical score termed quickSOFA (qSOFA): respiratory rate \>22breaths/min, altered mentation, or systolic blood pressure \<100mmHg.
* Cardiorespiratory fitness \<80% of age and sex-predicted norms
* Can commit to attending 3 exercise sessions a week for 12-weeks

Exclusion Criteria:

* Unable to provide informed consent
* On supplemental oxygen
* Known previous cardiac or cerebral vascular events in the past 90 days
* Diabetes
* Autoimmune diseases or on daily immunomodulatory drugs
* Obstructive sleep apnea
* Uncontrolled hypertension
* Known pregnancy/ intending to get pregnant within 28 days of enrolling in the study or breastfeeding
* Desaturation during exercise SpO2\<85%
* Cardiovascular contraindication or musculoskeletal limitations to exercise as assessed during the cardiopulmonary exercise test

Where it's running

• St. Paul's Hospital - Centre for Heart Lung Innovation
  Vancouver, British Columbia, Canada Recruiting

Study contacts

• Principal investigator: Graeme Koelwyn, PhD — University of British Columbia
• Study coordinator: Graeme Koelwyn, PhD
• Email: graeme.koelwyn@hli.ubc.ca
• Phone: 604-682-2344

Similar studies

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.