Pre-surgery sleep and recovery after breast cancer surgery
Role of Preoperative Sleep Quality in Predicting Postoperative Inflammation, Pain Severity, and Analgesic Requirement After Breast Cancer Surgery
This will test whether sleep quality before elective breast cancer surgery predicts postoperative inflammation, pain levels, and pain medicine use in women.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | Female |
| Sponsor | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital Academic / other |
| Locations | 1 site (Ankara, Yenimahalle) |
| Trial ID | NCT07547774 on ClinicalTrials.gov |
What this trial studies
This prospective observational study enrolls women aged 18–70 undergoing elective breast cancer surgery and collects preoperative sleep data with the Pittsburgh Sleep Quality Index (PSQI). Systemic immune-inflammation will be quantified using the Systemic Immune-Inflammation Index (SII) derived from routine blood counts. Postoperative pain will be measured with the Visual Analog Scale (VAS) and total analgesic consumption recorded during the first 24 hours. Analyses will examine whether preoperative PSQI scores are associated with postoperative SII, pain intensity, and analgesic requirements while accounting for clinical covariates.
Who should consider this trial
Good fit: Women aged 18–70 scheduled for elective breast cancer surgery with ASA physical status I–III who can understand and complete the PSQI and provide informed consent are ideal candidates.
Not a fit: Patients with active infection, chronic inflammatory or autoimmune disease, recent steroid/immunosuppressant use, diagnosed obstructive sleep apnea, severe cognitive impairment, planned emergency surgery, or those unwilling/unable to consent are unlikely to benefit or are excluded.
Why it matters
Potential benefit: If successful, this could identify poor preoperative sleep as a modifiable risk factor so clinicians can target sleep before surgery to reduce inflammation and pain.
How similar studies have performed: Prior observational studies have linked poor sleep to higher inflammatory markers and greater postoperative pain, but results are mixed and this specific focus on breast cancer surgery remains relatively underexplored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients aged 18 to 70 years * Scheduled for elective breast cancer surgery * American Society of Anesthesiologists (ASA) physical status I to III * Able to understand and complete the Pittsburgh Sleep Quality Index (PSQI) * Willing to participate in the study * Provided written informed consent Exclusion Criteria: * Active infection * History of chronic inflammatory disease or autoimmune disease * Use of steroids or immunosuppressive drugs within the past 6 months * Known diagnosis of obstructive sleep apnea syndrome * Severe cognitive impairment preventing completion of the questionnaire * Planned emergency surgery * Refusal to participate or failure to provide informed consent
Where this trial is running
Ankara, Yenimahalle
- Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital Clinic of Anesthesiology and Rea — Ankara, Yenimahalle, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Mustafa Kemal Şahin
- Email: mksahin@msn.com
- Phone: +905075800976
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.