Pre-surgery conditioning and optimization for hip or knee replacement
Official title: Preoperative Optimization Before Total Hip or Knee Replacement Surgery - a Controlled, Randomized, Single-blind Study
Run by Medical University Innsbruck · NCT07394582 · Data updated 2026-11-12
This will try a tailored pre-surgery program for adults with higher surgical risk (ASA ≥3) who are waiting at least eight weeks for elective hip or knee replacement to see if it improves recovery and reduces complications.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 99 Years |
| Sex | All |
| Enrollment | 180 (estimated) |
| Sponsor | Medical University Innsbruck Academic / other |
| Locations | 1 site (Innsbruck, Tyrol) |
| Status | Recruiting |
| Started | February 5, 2026 |
| Main results expected | February 5, 2034 |
| Study ends | February 5, 2034 |
| Registry record updated | February 11, 2026 |
| Trial ID | NCT07394582 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18–99 with ASA physical status ≥3 who are scheduled for elective total hip or knee replacement with at least eight weeks before surgery and who can give informed consent.
✕Probably not a fit
Patients who are pregnant or breastfeeding, have contraindications to physical training, severe cognitive impairment, very recent major trauma or blood loss, are enrolled in another interventional study, or need surgery sooner than eight weeks are unlikely to be eligible or to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The PrOpE protocol randomizes 180 adults scheduled for elective total hip or knee replacement who are classified ASA ≥3 to either usual care or an individualized preoperative optimization (prehabilitation) program. The multi-week intervention can include tailored physical training, nutritional support, medication review, and stress or anxiety management delivered before surgery. The main aim is to test the feasibility of delivering this comprehensive program and to explore effects on postoperative recovery, complications, function, and quality of life. The single-center study enrolls adults 18–99 with at least an eight-week wait to surgery and capacity to consent at the Medical University Innsbruck.
Why it matters
Potential benefit: If successful, the program could help patients recover faster, have fewer complications, and return to normal activities sooner after hip or knee replacement.
How similar studies have gone: Previous prehabilitation programs for joint replacement have shown modest improvements in fitness and some recovery measures but results are mixed, so this comprehensive program builds on limited and variable evidence.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * American Society of Anesthesiologists (ASA) physical status classification ≥ 3 * Age between 18 and 99 years * All sexes * Elective total hip or knee replacement with a waiting period of ≥ 8 weeks between surgical indication and surgery * Ability to understand the nature, content, and procedures of the study and to provide written informed consent * Written informed consent obtained prior to any study-related procedure Exclusion Criteria: * Pregnancy or active breastfeeding * Severe trauma or major blood loss within 14 days prior to enrollment * Participation in another pharmacological or interventional clinical study * Contraindications to physical training * Pre-existing diagnosis of moderate to severe dementia
Where it's running
-
Medical University Innsbruck
Innsbruck, Tyrol, Austria Recruiting
Study contacts
- Principal investigator: Barbara Sinner, MD, MBA — Medical University Innsbruck
- Study coordinator: Helmut Raab, MD
- Email: helmut.raab@tirol-kliniken.at
- Phone: +435050480833
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Feasibility of high-dose multimodal prehabilitation for women awaiting gynecologic cancer surgery
This study tests whether a high-dose, multimodal prehabilitation program can be delivered before gynecologic cancer surgery and whether patients prefer in-person, remote, or education-only approaches.
-
Preoperative functional optimization for adults undergoing major cardiac or abdominal surgery
This study tests a four‑week prehabilitation program to improve fitness before elective major cardiac or abdominal surgery.
-
Multimodal Prehabilitation for Gastric Cancer Patients
This program tests whether a combined pre- and post-operative wellness plan can reduce inflammation after gastric cancer surgery in adults.
-
Wireless home prehabilitation for older adults with NSCLC awaiting lung surgery
This study tests whether a personalized home exercise program guided by wearable devices can improve lung function for older NSCLC patients preparing for curative lung surgery.
-
Maltodextrin in the Preoperative Fast for Kids in ERAS
This pilot study tests whether giving maltodextrin before surgery helps reduce anxiety and improve recovery in children aged 3 to 8 undergoing elective day surgery.
-
VR preparation for kids before surgery
A small study tests whether a virtual reality tour of the hospital before surgery helps kids aged 3–12 feel less anxious and more cooperative.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.