Pre-infusion aerobic cycling to help maintain fitness during chemotherapy
Official title: Pre-infusion Aerobic Cycling Exercise for CardioRespiratory Fitness in Cancer Patients
Run by University of Dublin, Trinity College · NCT07182773 · Data updated 2026-11-12
This trial will try 30 minutes of moderate-intensity cycling on infusion days to see if it helps adults with stage I–IIIc breast, ovarian, or colorectal cancer keep their cardiorespiratory fitness while receiving chemotherapy or immunotherapy.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | University of Dublin, Trinity College Academic / other |
| Drugs / interventions | chemotherapy, immunotherapy |
| Locations | 1 site (Dublin) |
| Status | Recruiting |
| Started | September 24, 2025 |
| Main results expected | September 2026 |
| Study ends | September 2027 |
| Registry record updated | May 4, 2026 |
| Trial ID | NCT07182773 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 with histologically confirmed stage I–IIIc breast, ovarian, or colorectal cancer who are scheduled for at least 12 weeks of curative-intent chemotherapy ± immunotherapy, can use an exercise bike independently, and have oncologist clearance are ideal candidates.
✕Probably not a fit
Patients with metastatic disease, those receiving concurrent chemoradiotherapy, or those with cardiac, cognitive, or other contraindications to cycling are excluded and unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults with stage I–IIIc breast, ovarian, or colorectal cancer who are scheduled for at least 12 weeks of curative-intent chemotherapy ± immunotherapy will be recruited and medically screened before participation. Participants will perform supervised moderate-intensity cycling for approximately 30 minutes on the day of infusion, guided by a physiotherapist on the treatment ward, across the treatment period. Cardiorespiratory fitness and safety will be monitored using preparticipation screening and CPET-derived measures, with adherence and functional outcomes tracked over time. The approach tests a convenient, patient-centered delivery model for aerobic exercise embedded into routine infusion visits.
Why it matters
Potential benefit: If successful, this approach could reduce or prevent declines in cardiorespiratory fitness during treatment, improving physical function and quality of life for patients undergoing chemotherapy.
How similar studies have gone: Systematic reviews and other exercise-oncology trials have shown aerobic exercise during treatment can improve cardiorespiratory fitness and quality of life, but supervised pre-infusion cycling on infusion days is a novel, less-studied delivery method.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged \>18. Histological confirmed diagnosis of stage I to IIIc breast, ovarian, or colorectal cancer. Scheduled to receive chemotherapy ± immunotherapy with curative intent over at least a 12-week period. Medical clearance from oncologist to partake in regular exercise in accordance with ACSM preparticipation screening algorithm. Able to use exercise bike independently. Ability to provide written informed consent. Exclusion Criteria: * Advanced/metastatic disease. Scheduled to receive concurrent chemoradiotherapy. New pain or other pain that would preclude ability to use bike. Inability to read and understand English. Deemed unfit to proceed from results of CPET. Unstable angina, arrhythmia, hypertension or decompensated heart failure. Dementia or psychiatric illness which would preclude safe independent exercise. Acute untreated embolus/infarct. Dissecting aneurysm. Acute myocarditis or pericarditis.
Where it's running
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Beacon Hospital Dublin
Dublin, Ireland Recruiting
Study contacts
- Study coordinator: Aoife McGovern
- Email: physiotherapy@beaconhospital.ie
- Phone: +3531 293 6692
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.