Pre-Emptive Parecoxib for Pain During CT-Guided Lung Nodule Localization

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, randomized, double-blind, placebo-controlled trial evaluating preoperative parecoxib sodium versus placebo in adults with NSCLC scheduled for VATS requiring CT-guided hook wire localization. Participants receive the study drug IV at varying times before localization to determine the best timing for pain relief. The trial uses a 2:1 randomization favoring parecoxib to collect timing data while preserving statistical power. Outcomes focus on peri-procedural pain and related comfort during localization. Eligibility includes adults with NSCLC, good functional status, and ability to use a pain scale.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Voluntarily agreed to participate in the study and signed the informed consent form approved by the Ethics Committee.
* Male or female adult patients aged 18 years or older.
* Histologically or cytologically confirmed non-small cell lung cancer (NSCLC) scheduled for Video-Assisted Thoracoscopic Surgery (VATS).
* Requires preoperative CT-guided hook wire localization of lung nodules.
* Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1.
* American Society of Anesthesiologists (ASA) physical status classification of I or II.
* Fully conscious with no psychiatric or neurological disorders, and capable of fully understanding and correctly using the Visual Analog Scale (VAS) for pain assessment.

Exclusion Criteria:

* Known history of hypersensitivity to parecoxib sodium, other COX-2 inhibitors, sulfonamides, aspirin, or other non-steroidal anti-inflammatory drugs (NSAIDs).
* History or presence of active peptic ulcer disease, gastrointestinal bleeding, or gastrointestinal perforation.
* Severe cardiovascular diseases, including but not limited to unstable angina, history of myocardial infarction within the past 6 months, severe arrhythmias, or poorly controlled hypertension.
* Coagulation disorders with a bleeding tendency (e.g., hemophilia) or currently receiving full-dose anticoagulation therapy, which the investigator believes may significantly increase the bleeding risk of the hook wire localization.
* Severe, uncontrolled pulmonary diseases (e.g., severe chronic obstructive pulmonary disease \[COPD\], interstitial pneumonia) that the investigator believes pose an unacceptable risk for the procedure.
* Currently using other analgesic medications that cannot be discontinued during the study period.
* Any other conditions that, in the investigator's judgment, might interfere with the outcome assessment or increase the risk to the subject.

Where it's running

• Shanghai Chest Hospital
  Shanghai, Shanghai Municipality, China Recruiting

Study contacts

• Principal investigator: Long Jiang, M.D. & Ph.D. — Shanghai Chest Hospital
• Study coordinator: Long Jiang, M.D. & Ph.D.
• Email: dylan919@me.com
• Phone: +862122200743

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Robot-assisted dye marking for lung nodule surgery

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.