Pre-cooling and sweet-tasting solutions to help with dental anesthesia in kids

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study explores pain-reduction strategies for pediatric dental injections. It has two phases: first, identifying which sweet-tasting solution (xylitol, monk fruit, erythritol, or honey) children prefer; second, a randomized trial with seven groups comparing pre-cooling, the chosen sweet solution, topical anesthesia, and their combinations. Primary outcome is pain on a visual analog scale, with secondary outcomes including behavioral responses, heart rate, and oxygen saturation. Approximately 220 children are planned to participate, aged 7–11, who require infiltration anesthesia and have Frankl scores of 3 or 4.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age group 7-11 years
2. Patients requiring infiltration anesthesia to fulfill dental therapeutic needs
3. Frankl behavior scale 3 and 4

Exclusion Criteria:

1. Failure to provide assent or consent
2. Allergy from local anesthetic solution
3. Systemic diseases such as diabetes that could affect pain perception
4. History of abscess or fistula at site of injection

Where it's running

• Faculty of Dentistry, British University in Egypt
  Cairo, El Sherouk, Egypt Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.