Postpartum high blood pressure: which medicine works better after delivery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized trial assigns 110 postpartum participants with hypertensive disorders of pregnancy to receive either labetalol or extended-release nifedipine. The goal is to see which medication better maintains blood pressure control beyond six weeks postpartum. Primary outcome is continued antihypertensive use beyond 6 weeks postpartum; secondary outcomes include readmissions, side effects, and need to switch or add another antihypertensive. Remote blood pressure monitoring is used to evaluate effectiveness. The study is conducted at UCLA with participants who delivered at the same institution.

Why it matters

Who can join: the full rules

Inclusion criteria:

Age ≥18 years Delivery at study institution at ≥28 weeks gestation Postpartum SBP \> 150 and/or DBP \> 100 OR 2 or more SBP \> 140 and/or DBP \> 90 within a 24-hour period Require initiation of an oral antihypertensive medication during postpartum hospital stay or within 7 days of discharge Treating obstetric team amenable to starting either study medication

Exclusion criteria:

Treated with oral antihypertensive medications prior to delivery Known allergies or contraindications to nifedipine or labetalol History of moderate persistent to severe asthma, chronic obstructive pulmonary disease, heart failure, or greater than first-degree atrioventricular heart block Unable to provide written informed consent in English

Where it's running

• UCLA Ronald Reagan
  Los Angeles, California, United States Recruiting

Study contacts

• Study coordinator: Tina A Nguyen, MD
• Email: tinaanguyen@mednet.ucla.edu
• Phone: 310-794-7274

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.