Postoperative pneumonia after coronary artery bypass grafting

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, single-center, observational cohort at Tomsk NRMC comparing patients who develop non-ventilator-associated nosocomial pneumonia after CABG with those who do not. Participants receive clinical, laboratory (CBC, metabolic panel, cardiac, inflammatory, infectious, and endothelial biomarkers), functional (ECG, echocardiography, ultrasound, spirometry, cardiopulmonary exercise testing), and radiologic (chest X-ray/CT) examinations. The study is unblinded and follows patients to identify factors linked to early and one-year cardiopulmonary prognosis. Data will be analyzed to define phenotype differences and risk factors that could inform prevention and management of postoperative respiratory and cardiovascular complications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years and older.
* Myocardial revascularization for CAD via CABG during the current hospitalization, in accordance with the indications defined by the ESC/EACTS Guidelines on Myocardial Revascularization \[DOI: 10.1093/eurheartj/ehy394\].
* Successful transfer from the intensive care unit to a general ward after surgery.
* One or more of the risk factor for nosocomial pneumonia \[doi: 10.15829/1560-4071-2024-6094\].
* Signed informed consent for participation in the study.

Pre-operative Exclusion Criteria:

* Acute coronary syndrome within the last 1 month.
* Combined surgical intervention for infective endocarditis.
* Combined valve surgery.
* Concomitant pulmonary disease requiring respiratory support prior to surgery.
* Presence of a tracheostomy.
* Participation in another clinical trial at the time of potential inclusion or within the preceding 3 months.
* Diagnosis of malignant neoplasms within the last 5 years.
* Life duration of less than 1 year.
* HIV infection.

Peri-operative Exclusion Criteria:

* Ventilator-Associated Pneumonia (VAP).
* Acute Myocardial Infarction after CABG and before inclusion.
* Acute Stroke after CABG and before inclusion.
* Pulmonary after CABG and before inclusion.
* Pulmonary Edema after CABG and before inclusion.
* Acute Respiratory Distress Syndrome (ARDS) after CABG and before inclusion.
* Pneumothorax requiring drainage after CABG and before inclusion.
* Delirium after CABG and before inclusion.
* Chronic Kidney Disease (CKD) Stage 4-5 / Acute Kidney Injury requiring renal replacement therapy or chronic dialysis.
* Any perioperative complication requiring the patient's return to the intensive care unit or prolonging the ICU stay beyond 48 hours.
* Any other active infectious process at a different site.
* Novel Coronavirus Infection (COVID-19).

Where it's running

• Cardiology Research Institute of Tomsk NRMC
  Tomsk, Tomsk Oblast, Russia Recruiting

Study contacts

• Principal investigator: Alla A. Boshchenko, MD, PhD — Cardiology Research Institute of Tomsk NRMC
• Study coordinator: Roman S. Timoshenko, MD
• Email: trs@cardio-tomsk.ru
• Phone: +79539244630

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.