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Postoperative outcomes and quality of life after endoscopic sinus surgery in Chinese CRSwNP patients

PREDICT: A Prospective, Multicenter Real-World Study to Describe the Clinical Outcome and Quality of Life in Chinese CRSwNP Patients

Observational AstraZeneca · NCT07446738

We will follow Chinese patients with chronic rhinosinusitis with nasal polyps who have endoscopic sinus surgery to see how their symptoms, quality of life, disease control, treatments, and costs change after surgery.

Quick facts

Study typeObservational
Enrollment200 (estimated)
SexAll
SponsorAstraZeneca Industry-sponsored
Locations16 sites (Changchun and 15 other locations)
Trial IDNCT07446738 on ClinicalTrials.gov

What this trial studies

This is a prospective, multicenter real-world observational project enrolling about 200 patients with CRSwNP who undergo endoscopic sinus surgery across roughly 20 centers in China. Participants will receive standard medical care decided by their treating physicians and attend scheduled clinical assessments and questionnaires. The study will collect data on symptom scores, disease control, recurrence, postoperative treatment patterns, quality of life, and economic burden. These collected outcomes will characterize real-world postoperative recovery and resource use in this population.

Who should consider this trial

Good fit: Adults aged 16 or older in China with a documented diagnosis of CRSwNP who undergo endoscopic nasal polypectomy and can provide informed consent and complete study questionnaires.

Not a fit: Patients who do not undergo surgery, who have significant comorbidities or psychiatric/cognitive impairment, who cannot complete questionnaires, or who are enrolled in other interventional trials are unlikely to benefit directly from this study's findings.

Why it matters

Potential benefit: If successful, the findings could help clinicians tailor postoperative follow-up and treatment to reduce recurrence, improve quality of life, and lower costs for patients with CRSwNP in China.

How similar studies have performed: Prior observational and interventional research has shown that endoscopic sinus surgery often improves symptoms and quality of life, but multicenter real-world data specifically describing recurrence patterns and economic burden in Chinese CRSwNP populations are limited.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. Participant must be 16 years of age or older, at the time of signing the informed consent.
2. Participants with a documented diagnosis of CRSwNP.
3. Endoscopic nasal polypectomy is performed during the screening period.
4. Voluntarily participate and sign the informed consent form as described in A 3.
5. No history or current psychiatric disorders, with normal cognitive functions including understanding, expression, and orientation.

Exclusion Criteria:

1. Any significant disease or disorder that the investigator believes may place the patient at risk or may affect the study results or the patient's ability to participate in the study.
2. Currently participating in an interventional study.
3. Patients who are unable to independently complete questionnaires due to language barriers or mental status.

Where this trial is running

Changchun and 15 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions Chronic Rhinosinusitis With Nasal PolypsCRSwNP
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.