Post-polypectomy scar: comparing four imaging methods to find residual tissue

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective, single-center study compares high-definition white light endoscopy, TXI, NBI, and a computer-aided detection system for detecting residual or recurrent tissue at post-polypectomy scars. Each scar is evaluated using all four techniques in random order by different experts, with biopsies taken from suspicious areas and histology used as the reference standard. Adults with a recent piecemeal EMR or ESD of colorectal lesions ≥15 mm are eligible, provided they are referred for scar review 3 to 6 months after treatment. The goal is to identify the imaging combination that yields the highest detection accuracy for residual neoplasia. The study is conducted at Hospital Universitario Virgen de las Nieves in Granada, Spain, led by its University Hospital gastroenterology department.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older.
* Previous endoscopic resection (endoscopic mucosal resection or endoscopic submucosal dissection) of a colorectal lesion ≥15 mm, performed 3 to 6 months before the surveillance colonoscopy.
* Histology of the resected lesion showing an adenoma or a sessile serrated lesion.
* Referral for endoscopic review of the post-polypectomy scar.
* Signed written informed consent.

Exclusion Criteria:

* Resected lesion \<15 mm.
* Histology of the resected lesion other than adenoma or sessile serrated lesion.
* Incomplete previous resection, or uncertainty about the completeness of the previous resection.
* Patients who, because of age or comorbidity, are not candidates for endoscopic surveillance.
* Failure to complete the study protocol, including biopsy of the scar.

Where it's running

• Department of Gastroenterology and Hepatology. Virgen de las Nieves University Hospitals
  Granada, Granada, Spain Recruiting
• Virgen de las Nieves University Hospital. Department of Gastroenterology and Hepatology
  Granada, Granada, Spain Recruiting

Study contacts

• Study coordinator: Eduardo Redondo Cerezo, MD, PhD
• Email: eredondoc@gmail.com
• Phone: +34 657373336

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.