Portable oxygen therapy for people with mild-to-moderate interstitial lung disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of portable oxygen therapy on individuals with fibrotic interstitial lung disease who experience low oxygen levels during physical activity. Participants will receive oxygen therapy for 8 weeks, along with individualized support from a respiratory therapist and educational materials. The goal is to assess improvements in quality of life, exercise tolerance, shortness of breath, and blood vessel function. The study aims to provide evidence for the efficacy of ambulatory oxygen therapy in patients who are normoxic at rest but hypoxemic during exertion.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals with fibrotic ILD (all sub-groups of ILD) who have normal oxygen saturation at rest (SpO2 \> 90%) but develop exertional hypoxemia as demonstrated by a SpO2 = 80-89% with activity (measured during 6MWT).

Exclusion Criteria:

* Use of home oxygen therapy within the previous year for the management of ILD, co-morbid conditions that may require oxygen therapy (such as COPD, cardiovascular disease, or other illnesses), or individuals that require the use of non-invasive ventilation. Additionally, individuals with significant cardiovascular, metabolic, neuromuscular or any other disease that could contribute to dyspnea or abnormal cardiopulmonary responses to exercise will be excluded. Individuals with musculoskeletal injuries that prevent them from completing cycle ergometry exercise trials and ambulation will also be excluded. Individuals with peripheral vascular disease will be excluded from measurement of vascular function (flow mediated dilation).

Where it's running

• Clinical Physiology Laboratory
  Edmonton, Alberta, Canada Recruiting

Study contacts

• Principal investigator: Mike Stickland — University of Alberta
• Study coordinator: Matt Rieger, PhD
• Email: mrieger@ualberta.ca
• Phone: 7804928027

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.