Portable LiverScope® MR device to measure liver disease in adults with MASLD/NAFLD
Accurate Point of Care Liver Disease Diagnostics
Try a small, portable MR-based device called LiverScope® to measure liver disease in adults with known or suspected MASLD/NAFLD and compare its measurements to standard MR exams.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 26 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, San Diego Academic / other |
| Locations | 1 site (La Jolla, California) |
| Trial ID | NCT07518784 on ClinicalTrials.gov |
What this trial studies
This Phase 2 observational project compares a compact, table-top MR-based device (LiverScope®) to conventional advanced liver MR exams in adults with known or suspected MASLD/NAFLD. Participants complete a one-time visit that includes a LiverScope® exam, a conventional MR exam, a blood draw, body measurements, and questionnaires. The study builds on phase 1 optimizations to the device and looks at how closely LiverScope® measurements match standard MR results. LiverScope® is not currently approved for clinical use and the goal is to determine its noninvasive measurement concordance with established MR techniques.
Who should consider this trial
Good fit: Adults aged 18 or older with known or clinically suspected MASLD/NAFLD, a BMI between 27 and 45 kg/m2, able to lie on the device table for about an hour and hold breaths for short periods, and willing to undergo MR, LiverScope®, blood draw, and questionnaires are ideal candidates.
Not a fit: People with chronic liver disease other than MASLD, those with MR contraindications, pregnant people or those trying to become pregnant, individuals outside the BMI range, or UCSD/Livivos study personnel are unlikely to benefit from participating.
Why it matters
Potential benefit: If successful, LiverScope® could make noninvasive liver monitoring faster and more accessible by offering a portable alternative to full MR exams.
How similar studies have performed: Established MR-based methods and elastography have proven useful for liver disease measurement, and an earlier phase of this project provided initial feasibility data, but LiverScope® itself remains a novel, not-yet-approved device under further testing.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Known or clinically suspected MASLD * BMI greater than 27 kg/m\^2 and less than 45 kg/m\^2 at the time of referral * Ability to lie on LiverScope® device table for about 60 minutes * Ability to hold breath repeatedly for about 20 seconds during MR and LiverScope® exams * Willing and able to undergo all study procedures Exclusion Criteria: * UCSD study personnel or Livivos study personne * Contraindications to MR * Potential participant states that she knows that she is pregnant, thinks she may be pregnant, or states that she is trying to become pregnant. * Known chronic liver disease other than MASLD
Where this trial is running
La Jolla, California
- University of California San Diego — La Jolla, California, United States (Recruiting)
Study contacts
- Principal investigator: Claude B Sirlin, MD — University of California, San Diego
- Study coordinator: Yesenia Covarrubias
- Email: ycovarrubias@health.ucsd.edu
- Phone: 858-246-2198
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.