POLE gene changes in high-risk endometrial cancer
The Role of POLE Mutation in High Risk Endometrial Cancer.
This project will test whether women with high-risk endometrial cancer have POLE gene mutations and whether those mutations change recurrence or survival.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Sex | Female |
| Sponsor | Far Eastern Memorial Hospital Academic / other |
| Locations | 1 site (Banqiao District, New Taipei) |
| Trial ID | NCT07114653 on ClinicalTrials.gov |
What this trial studies
This observational, single-center analysis will review high-risk and recurrent endometrial cancer cases treated at a tertiary referral hospital and perform POLE mutation testing on available tumor samples. The prevalence of POLE mutations in this real-world high-risk population will be reported. Clinical outcomes including recurrence and overall survival will be compared between POLE-mutant and non-mutant cases using survival analysis and appropriate statistical methods. The dataset is retrospective and limited to patients treated at Far Eastern Memorial Hospital.
Who should consider this trial
Good fit: Women with high-risk or recurrent endometrial cancer who were treated at Far Eastern Memorial Hospital and have tumor tissue available for POLE testing.
Not a fit: Patients without high-risk disease, those treated outside the study center, or those lacking adequate tumor tissue are unlikely to benefit directly from this analysis.
Why it matters
Potential benefit: If successful, the findings could help clinicians better predict prognosis and tailor follow-up or treatment decisions for women with high-risk endometrial cancer.
How similar studies have performed: Prior research in endometrial cancer has shown POLE mutations are relatively uncommon and often associated with favorable outcomes, but evidence specific to high-risk or recurrent cases is limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * women with high-risk for recurrent endometrial cancer Exclusion Criteria: * Nil
Where this trial is running
Banqiao District, New Taipei
- Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital — Banqiao District, New Taipei, Taiwan (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.