Polarized light therapy to reduce radiation dermatitis in breast cancer patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This assessor-blinded randomized study compares standard skin care alone to standard skin care plus polarized polychromatic non-coherent light therapy for acute radiation dermatitis during hypofractionated whole-breast irradiation after breast-conserving surgery. Participants begin the polarized light treatment on day one of radiotherapy and receive it three times per week during about three weeks. Outcomes include objective ultrasound measurements of dermal thickness and clinical dermatitis severity using RTOG criteria. The trial aims to determine if this non-invasive adjunct can improve skin toxicity and patient comfort. A secondary goal is to explore potential improvements in treatment adherence and quality of life.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Female patients aged 35-55 years.
2. Histologically confirmed primary unilateral breast cancer.
3. Status post breast-conserving surgery (lumpectomy).
4. Planned for hypo fractionated whole-breast irradiation (HFWBI).
5. Scheduled to receive a total radiation dose of 40-42.5 Gy delivered in 15-16 fractions over approximately 3 weeks.
6. Ability to understand study procedures and provide written informed consent.

Exclusion Criteria:

1. Previous radiotherapy to the same breast or thoracic region.
2. Bilateral breast cancer.
3. Metastatic or advanced systemic disease.
4. Prior mastectomy.
5. Active skin infection in the irradiated area.
6. Pre-existing dermatologic disorders affecting the breast skin (e.g., eczema, psoriasis, dermatitis).
7. Concurrent chemotherapy during radiotherapy.
8. Presence of cardiac pacemaker or implantable electronic device in the treatment field.
9. Open wounds or ulceration in the irradiated breast region.
10. Any medical condition judged by the investigator to interfere with study participation or outcome assessment.

Where it's running

• Out patient clinic , faculty of Physical Therapy, Beni Sueif university
  Banī Suwayf, Egypt Recruiting

Study contacts

• Study coordinator: Marwa Elsayed Mohamed Lecturer, Ph.D
• Email: Marwa.elsayed@pt.bsu.edu.eg
• Phone: 01141825442

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Exergames-acceptance and Commitment Therapy for Breast Cancer Depression and Anxiety

  This trial tests whether a combined exergame-based program with acceptance and commitment therapy helps reduce depression and anxiety in breast cancer survivors compared with ACT alone or standard care.

  Recruiting Universiti Sains Malaysia · Xinxiang, Henan · NCT07721753

• Home-based ear vagus nerve stimulation for breast cancer pain and symptoms

  This trial will test whether a handheld at-home transcutaneous auricular vagus nerve stimulation (taVNS) device can reduce pain and other symptoms in breast cancer survivors with ongoing moderate pain.

  Recruiting Florida State University · Tallahassee, Florida · NCT07500012

• Electroacupuncture vs. Ear Acupressure for Breast Cancer–Related Joint Pain

  This trial tests whether electroacupuncture or ear acupressure can lessen joint pain caused by endocrine therapy in breast cancer survivors compared with a waitlist control.

  Recruiting at 6 sites First Teaching Hospital of Tianjin University of Traditional Chinese Medicine · Wuhan, Hubei and 5 other locations · NCT07490938

• How short aerobic workouts affect tumor cells in breast cancer survivors

  This will test whether a single session of moderate or high intensity aerobic exercise changes circulating myokines and tumor cell responses in premenopausal women who survived stage II–III triple‑negative breast cancer compared with matched healthy women.

  Recruiting Riga Stradins University · Riga, Dzirciema Street 16 · NCT07439458

• Real-world use of EndoPredict to guide treatment in early HR+/HER2- breast cancer

  This tests whether the EndoPredict genomic test can predict 10-year relapse risk and help decide if people with early HR+/HER2- breast cancer need chemotherapy in addition to hormone therapy.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07379918

• Online psychoeducation to improve well-being after breast cancer

  This trial tests whether a 6-week online psychoeducation program can help women who finished breast cancer treatment at least a year ago feel better psychologically and improve their quality of life.

  Recruiting Uskudar University · Istanbul · NCT07284030

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.