Clinical trial Recruiting at 1 site Interventional Ages 18 to 52 Women only

Platelet-rich plasma to prevent uterine scar problems after cesarean

Official title: Platelet Rich Plasma for the Treatment of Uterine Scar

Run by The University of Texas Health Science Center, Houston · NCT05224726 · Data updated 2026-11-12

This test will see if applying your own platelet-rich plasma to the uterine incision at an elective term cesarean can reduce scar-related bleeding, pain, and menstrual problems.

Quick facts

Study typeInterventional
Ages18 Years to 52 Years
SexWomen only
Enrollment40 (estimated)
SponsorThe University of Texas Health Science Center, Houston
Academic / other
Locations1 site (Ramat Gan, Center)
StatusRecruiting
StartedJuly 19, 2025
Main results expectedJuly 1, 2028
Study endsJuly 1, 2028
Registry record updatedSeptember 30, 2026
Trial IDNCT05224726 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Women with a term pregnancy (≥37 weeks) scheduled for an elective cesarean who do not have exclusion conditions such as very low platelets or non-cesarean uterine scars would be ideal candidates.

Probably not a fit

Patients with thrombocytopenia, connective tissue disease, prior non-cesarean uterine surgery, or congenital uterine malformations are excluded and are unlikely to benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Participants undergoing elective cesarean delivery at term will have a sample of their blood processed into platelet-rich plasma (PRP) during the operative visit. The PRP preparation or a placebo will be applied to the uterine scar site at the time of closure. Outcomes will focus on healing-related measures and clinical complaints such as post-cesarean bleeding, pelvic pain, and menstrual irregularities linked to uterine scar defects. The approach uses autologous material to concentrate growth factors that may enhance local wound repair.

Why it matters

Potential benefit: If successful, this could reduce the frequency or severity of uterine scar defects and the bleeding, pain, or menstrual issues that follow some cesarean deliveries.

How similar studies have gone: PRP has shown promising results for wound healing and endometrial/follicular support in other surgical and reproductive settings, but its use specifically to prevent cesarean-related uterine scar defects is relatively novel and not yet widely proven.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion criteria:

* Women undergoing elective cesarean delivery
* Term pregnancy (≥37 weeks of gestation)

Exclusion criteria:

* Thrombocytopenia (CBC Platelet count \<70,000)
* Connective tissue disease
* Uterine scars other than cesarean (s/p myomectomy, s/p cornual resection)
* Malformed uterus (unicornuate, bicornuate, didelphic)

Where it's running

  • Sheba Medical Center
    Ramat Gan, Center, Israel
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.