Platelet-rich plasma for jaw fracture healing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, parallel-group trial compares open reduction and internal fixation with titanium miniplates plus autologous PRP versus fixation without PRP in adults with maxillary or mandibular fractures. It uses a standardized protocol at a single center in Lahore, Pakistan, with follow-up through 6 months and CBCT-based assessment of bone healing. Eligible participants are adults 18 or older needing surgical fixation and able to attend follow-up visits. Outcomes focus on bone density at the fracture site and differences between maxillary and mandibular healing. The study aims to determine if PRP enhances bone regeneration in maxillofacial trauma beyond standard fixation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older
* Fracture of the maxilla or mandible confirmed by clinical examination and panoramic radiograph
* Fracture requiring open reduction and internal fixation with titanium miniplates
* Willing and able to provide written informed consent and to attend all follow-up visits up to 6 months

Exclusion Criteria:

* Uncontrolled diabetes mellitus
* Bleeding or coagulation disorders (e.g., haemophilia, von Willebrand disease)
* Platelet disorders or thrombocytopenia
* Chronic renal failure
* Hepatic disease
* Active malignancy, or current chemotherapy or radiotherapy
* Osteoporosis or other metabolic bone disease
* Immunocompromised state (e.g., HIV/AIDS, long-term corticosteroid or immunosuppressive therapy)
* Current use of anticoagulant or antiplatelet medication
* Pregnancy or lactation
* Multiple or pathological fractures
* Refusal to provide informed consent

Where it's running

• Institute of Dentistry; CMH Lahore Medical College
  Lahore, Punjab Province, Pakistan Recruiting
• CMH Lahore
  Lahore, Pakistan Completed

Study contacts

• Study coordinator: Shanza Razzak
• Email: shanzarazzaq@gmail.com
• Phone: +923225467436

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.