Platelet-rich fibrinogen to help socket healing after back-tooth extraction in older adults
Official title: Wound Healing Outcomes in Aged Extraction Patient With Platelet Rich Fibrinogen
Run by University of Nebraska · NCT06943846 · Data updated 2026-11-12
This test will try placing platelet-rich fibrin (PRF) into a posterior tooth extraction site to see if it improves healing in participants aged 14–18 and 50–80 who need a back tooth removed.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 14 Years to 80 Years |
| Sex | All |
| Enrollment | 12 (estimated) |
| Sponsor | University of Nebraska Academic / other |
| Drugs / interventions | methotrexate |
| Locations | 1 site (Lincoln, Nebraska) |
| Status | Recruiting |
| Started | May 1, 2025 |
| Main results expected | January 1, 2027 |
| Study ends | May 1, 2027 |
| Registry record updated | October 8, 2026 |
| Trial ID | NCT06943846 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Patients of the UNMC College of Dentistry who need a posterior tooth extraction, are willing to give consent/assent and blood/tissue samples, and fall into the study age groups are ideal candidates.
✕Probably not a fit
People with systemic conditions or medications that impair wound healing, current smokers or vapers, pregnant individuals, or those unable to consent are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Twelve patients at the University of Nebraska Medical Center needing a posterior tooth extraction will be enrolled, split into two age groups (six aged 14–18 and six aged 50–80). On the day of extraction baseline clinical measures, a CBCT radiograph, gingival crevicular fluid samples, and an HbA1c finger stick will be collected; half the participants will have blood drawn to produce PRF that is placed into the extraction socket. Small soft tissue samples will be taken at extraction and again at two weeks (suture removal), and a final radiograph will be obtained at three months. All soft tissue specimens will undergo immunofluorescence analysis to compare healing markers between PRF-treated and untreated sockets.
Why it matters
Potential benefit: If successful, PRF placed in the extraction socket could improve soft tissue and early bone healing after extraction, possibly reducing complications and easing later implant placement.
How similar studies have gone: Small clinical studies and case series using platelet-rich fibrin for oral surgery and extraction sockets have shown promising improvements in soft tissue healing and bone preservation, though results vary and larger trials are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient at University of Nebraska Medical Center (UNMC) College of Dentistry * Requires extraction of posterior tooth * Able and willing to provide consent/assent Exclusion Criteria: * Systemic conditions that delay wound healing * Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs), methotrexate, bisphosphonates or other drugs that inhibit wound healing Smoking and vaping Pregnancy
Where it's running
-
University of Nebraska Medical Center College of Dentistry
Lincoln, Nebraska, United States Recruiting
Study contacts
- Principal investigator: Amy C Killeen, DDS, MS — University of Nebraska
- Study coordinator: Amy C Killeen, DDS, MS
- Email: akilleen@unmc.edu
- Phone: 402-472-7848
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.