Plain-language comparison of plasma-treated vs HF-etched lithium disilicate crowns
Official title: Effect of Innovative Treatment With Atmospheric-Pressure Gaseous Plasma on the Clinical Success and Survival of Full- and Partial-Coverage Dental Crowns Made of Lithium Disilicate Ceramic
Run by University of Ljubljana, Faculty of Medicine · NCT07876167 · Data updated 2026-11-12
This study tests whether air-plasma treatment on lithium disilicate crowns works as well as the standard hydrofluoric acid etching before cementing them to teeth.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 30 (estimated) |
| Sponsor | University of Ljubljana, Faculty of Medicine Academic / other |
| Locations | 1 site (Ljubljana) |
| Status | Recruiting |
| Started | September 2026 |
| Main results expected | September 2029 |
| Study ends | October 2030 |
| Registry record updated | October 15, 2026 |
| Trial ID | NCT07876167 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults requiring posterior partial- or full-coverage lithium disilicate crowns and meeting good oral hygiene and general health criteria.
✕Probably not a fit
Patients with active periodontal disease, dentin hypersensitivity, or contraindications to prosthodontic treatment may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind trial compares two surface-treatment methods for lithium disilicate crowns placed on posterior teeth: atmospheric-pressure nonthermal plasma (APP) pretreatment versus conventional hydrofluoric acid (HF) etching. Adults needing partial- or full-coverage LDC crowns are assigned to one of the pretreatments before adhesive cementation, with follow-up visits at 1 week, and 1, 3, 6, and 12 months to assess crown survival and oral-health-related quality of life. The study aims to determine if APP can provide comparable or superior clinical performance and bonding compared with HF etching, while reducing HF-related safety concerns. Outcomes include clinical success, crown survival, and patient-reported quality of life. The trial is sponsored by the University of Ljubljana and involves multiple Slovenian institutions.
Why it matters
Potential benefit: If successful, APP pretreatment could offer a safer or equally effective alternative to HF etching for lithium disilicate crowns.
How similar studies have gone: Preclinical and early clinical work suggested APP can modify ceramic surfaces, but long-term clinical outcomes with APP are not yet well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * No systemic contraindications to prosthodontic treatment * Adequate oral hygiene * Signed informed consent to participate in the study * Posterior teeth (premolars or molars) * Involvement of the entire occlusal surface * Partial- or full-coverage lithium disilicate ceramic restoration * Vital and healthy dental pulp Exclusion Criteria: * Orofacial pain * Allergy to latex, dental composites, or acrylates * Pregnancy or breastfeeding * Clinical signs of periodontal or periapical inflammation * Dentin hypersensitivity * Pain on biting or spontaneous pain * Pathological findings on dental radiographs * Untreated periodontal disease * Hypoplastic enamel defects
Where it's running
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Faculty of Medicine, University of Ljubljana
Ljubljana, Slovenia Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.