Effect of Nanostructured Alumina Coating on Bond Strength of Zirconia Resin-bonded Fixed Dental Prostheses
Official title: Effect of Nano-structured Alumina Coating on the Bond Strength of Zirconia Resin-bonded Fixed Dental Prostheses
Run by University of Ljubljana, Faculty of Medicine · NCT04693949 · Data updated 2026-11-12
This trial tests whether a nanostructured alumina coating on zirconia surfaces improves the bonding and survival of resin-bonded fixed dental prostheses for replacing missing incisors.
Quick facts
| Study type | Interventional |
|---|---|
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | University of Ljubljana, Faculty of Medicine Academic / other |
| Locations | 1 site (Ljubljana) |
| Status | Recruiting |
| Started | January 3, 2018 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2030 |
| Registry record updated | June 23, 2026 |
| Trial ID | NCT04693949 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients needing replacement of a missing central or lateral incisor with a zirconia RBFDP and adequate enamel bonding surface, without signs of bruxism or active periodontal disease.
✕Probably not a fit
Patients with inadequate edentulous space, poor bonding surfaces, bruxism, active periodontal disease, or conditions interfering with study conduct may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective, randomized, double-blind trial compares nanostructured alumina coating (NAC) versus conventional airborne particle abrasion (APA) as surface pretreatments for zirconia resin-bonded fixed dental prostheses (RBFDPs) used to replace missing central or lateral incisors. Eligible healthy patients with a missing incisor, evaluated by calibrated dentists, are assigned to one of two groups and receive RBFDPs from the same operator to ensure consistency. The primary outcome is retention and clinical survival of the NAC-pretreated versus APA-pretreated restorations, with secondary considerations on debonding events and long-term integrity. The study addresses whether NAC can provide superior bonding without compromising zirconia strength, potentially reducing debonding-related failures. The University of Ljubljana leads the trial with no listed collaborators at other sites, and it targets standard dental clinical practice settings.
Why it matters
Potential benefit: If successful, NAC pretreatment could improve bond durability and reduce debonding in zirconia RBFDPs, potentially extending their clinical lifespan for patients missing incisors.
How similar studies have gone: Prior studies have shown mixed results for surface pretreatments on zirconia bonding; this trial explores NAC as a novel alternative with potential for improved outcomes in this specific prosthesis application.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1\. Patients with missing central or lateral incisor Exclusion Criteria: 1. inadequate edentulous space for the pontic 2. signs of bruxism 3. abutment tooth with active periodontal or periapical disease 4. inadequate enamel bonding surface of the abutment tooth 5. inadequate interocclusal space for a retainer wing and a proximal connector 6. pontic guidance 7. physical or psychological disease likely to interfere with normal conduct of the study
Where it's running
-
Medical Faculty - University of Ljubljana Ljubljana
Ljubljana, Slovenia Recruiting
Study contacts
- Study coordinator: Tine Malgaj, DMD
- Email: tine.malgaj@mf.uni-lj.si
- Phone: +386 31 410140
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.