Placement of an Ommaya reservoir during biopsy for brain tumor patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational trial evaluates the use of an Ommaya reservoir, a small device implanted under the scalp, during a biopsy to facilitate the longitudinal collection of cerebrospinal fluid (CSF) biomarkers in patients with brain tumors. The study aims to determine the effectiveness of this minimally invasive approach for monitoring tumor growth and response to therapy over time. By allowing for repeated sampling of CSF without the need for additional spinal taps, the trial seeks to enhance our understanding of tumor behavior and treatment efficacy. The ultimate goal is to identify biomarkers that could guide personalized treatment strategies for brain tumor patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Clinical and radiographic evidence suggesting a diagnosis of a brain tumor
* Planned biopsy for suspected or previously diagnosed brain tumor as part of routine clinical care at Mayo Clinic (Rochester, Minnesota \[MN\])
* Willingness of the patient to provide informed consent
* Patient is willing to have their Ommaya sampled on at least 2 future occasions
* Patients is willing to have CSF banked through the neuro-oncology biorepository (requires a separate signature)

Exclusion Criteria:

* Vulnerable populations including pregnant women, prisoners, and individuals \< 18 years old
* Patients who are not appropriate candidates for biopsy due to current or past medical history or uncontrolled current illness
* Prior history of any wound infection
* Any patient who the surgeon feels is not an optimal candidate for Ommaya reservoir placement. Such reasons may include, but will not be limited to, surgical anatomy, clinical evidence of immunosuppression, and/or elevated risk of wound infection due to diabetes, smoking history, morbid obesity, or any other concerns

Where it's running

• Mayo Clinic in Rochester
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Terry C. Burns, M.D., Ph.D. — Mayo Clinic in Rochester

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.