Photon-counting CT to improve tumor targeting and dose accuracy in personalized radiotherapy (ANTHEM)

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational imaging protocol uses photon-counting CT (PCCT) during radiotherapy planning to obtain higher-resolution, spectrally enriched images for patients with challenging tumor locations or who require cardiac-directed radiation. Images and derived tissue-characterization data will be compared with conventional planning information to examine differences in target delineation and dose calculations. The study enrolls adults treated with photon or proton radiotherapy at the enrolling center and collects imaging and dosimetric metrics without changing the prescribed therapy. Results will inform whether PCCT-derived information could be incorporated into routine radiotherapy workflows for more precise planning.

Why it matters

Who can join: the full rules

Inclusion criteria:

* ≥18 years old patients
* tumors located in challenging anatomical regions (brain, head and neck, liver, pancreas prostate), or Cardiac disease requiring RT by photon or proton at our Institution.

Exclusion criteria:

\- 18 years old patients

Where it's running

• IRCCS Humanitas Research Hospital
  Rozzano, Milan, Italy Recruiting

Study contacts

• Principal investigator: Marta Scorsettti, MD, radiation oncologist — Humanitas University
• Study coordinator: Research study coordinator
• Email: laura.bonavita@humanitas.it
• Phone: +39 0282247026

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.