Photoacoustic imaging of blood vessels and oxygen in the lower leg and foot

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will enroll adults with diagnosed lower extremity artery disease (LEAD) and healthy volunteers to undergo three-dimensional photoacoustic computed tomography (PACT) scans of the feet. The PACT system produces high-resolution images of millimeter-scale microvessels and can estimate blood oxygenation without using contrast agents. Imaging findings will be compared with standard clinical evaluations and ultrasound to determine what additional vascular and oxygenation information PACT provides. The study is observational and aims to define PACT's feasibility and potential clinical role across different stages of LEAD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Inclusion of the case group 1) LEAD patients; 2) Patients voluntarily take part in the study and write informed consent.
2. Inclusion of the control group 1) Patients without LEAD by ultrasound and clinical diagnosis; 2) Patients voluntarily take part in the study and write informed consent.

Exclusion Criteria:

1. age \<18 years;
2. pregnant women, nursing mothers and pregnant women in preparation;
3. with laser operation contraindication (for example, received a photodynamic therapy in the last month);
4. with metal implants in lower legs or feet;
5. with a history of mental illnesses or abuse of drug and alcohol;

7\) with blood phobia or pathological hypotension; 8) with cerebral hemorrhage or peripheral vascular bleeding risk, or history of stroke; 9) with wounds in lower legs or feet; 10) unable or uncooperative with the experimenter.

Where it's running

• the Third Affiliated Hospital of Sun Yat-sen University
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Study coordinator: Jia Liu, Doctor
• Email: liujia45@mail.sysu.edu.cn
• Phone: 8602085252010

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.