Pharmacist-guided genetic testing for antidepressant therapy
Official title: Pharmacist Guided Pre-emptive Pharmacogenetic Testing in Antidepressant Therapy
Run by University of Basel · NCT04507555 · Data updated 2026-11-12
This study tests if using genetic testing to guide antidepressant treatment helps people with depression feel better compared to standard care.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 190 (estimated) |
| Sponsor | University of Basel Academic / other |
| Locations | 4 sites (Münchenbuchsee, Canton of Bern and 3 other locations) |
| Status | Recruiting |
| Started | September 15, 2020 |
| Main results expected | December 31, 2025 |
| Study ends | December 31, 2025 |
| Registry record updated | January 20, 2025 |
| Trial ID | NCT04507555 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18 and older diagnosed with moderate to severe unipolar depression or recurrent depressive disorder.
✕Probably not a fit
Patients with acute suicide risk, psychotic symptoms, or other serious psychiatric disorders may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study at the Solothurn Psychiatric Clinic evaluates the effectiveness and tolerability of antidepressant medications by comparing a group receiving pharmacist-guided pharmacogenetic testing to a standard care group. In the intervention group, medication selection and dosing are tailored based on genetic testing results, while the standard group follows conventional practices without genetic input. Patients are monitored for progress after the first week of hospitalization, with random assignment to groups based on the need for medication adjustment. All medications used are approved for treating depression in Switzerland.
Why it matters
Potential benefit: If successful, this approach could lead to more effective and personalized antidepressant therapy for patients with depression.
How similar studies have gone: Other studies have shown promise in using pharmacogenetic testing to optimize antidepressant therapy, suggesting this approach may be beneficial.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥ 18 years old * Diagnosis unipolar moderate or severe depressive episode or recurrent depressive disorder (ICD10: F32.1/32.2/33.1/33.2) * HAM-D17 ≥ 17 Exclusion Criteria: * Acute suicide risk * Psychotic symptomatology * Other acute serious psychiatric disorder other than depression * Excessive consumption of alcohol and/or drugs * Severe acute - or severe chronic somatic diseases * Pregnant / lactating women * Under current treatment with fluoxetine
Where it's running
-
Privatklinik Wyss
Münchenbuchsee, Canton of Bern, Switzerland Recruiting -
Psychiatrische Dienste Solothurn
Solothurn, Canton of Solothurn, Switzerland Recruiting -
Luzerner Psychiatrie AG
Sankt Urban, Switzerland Recruiting -
Psychiatrische Universitätsklinik Zürich
Zurich, Switzerland Recruiting
Study contacts
- Principal investigator: Thorsten Mikoteit, PD Dr. med. — Psychiatrische Dienste Solothurn
- Study coordinator: Céline Stäuble, MSc
- Email: celine.staeuble@unibas.ch
- Phone: +41 61 207 61 78
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.