Phage-based approach to support gut and skin health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study tests two bacteriophage therapies designed to target specific gut bacteria (E. coli strains) and skin-associated bacteria (Staphylococcus aureus) to see if they improve GI symptoms and skin quality. Participants will receive one of two phage formulations or placebo for 4 weeks, with safety and efficacy monitored throughout. The trial includes adults aged 18–75 with BMI under 30 who experience mild to moderate GI distress, and excludes those with major comorbidities, recent antibiotic use, or other medications that could affect outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Between 18-75 years old
* BMI \<30
* Experiencing mild-moderate gastrointestinal distress/ abdominal pain, bloating, constipation, and/or diarrhea

Exclusion Criteria:

* Younger than 18 years old or greater than 75 years old
* BMI \>29.9
* Antibiotic use in the past 2 months
* Use of statins, metformin, prescription NSAIDs, and MAO inhibitors, or other medications that could interfere with study outcomes, as determined by the study PI
* Current diagnosis of cancer, liver or kidney disease, gastrointestinal diseases, or cardiometabolic disease (diabetes, cardiovascular disease)
* Individuals with allergies to capsule ingredients
* Pregnant or breastfeeding individuals
* Excess alcohol consumption (≥4 drinks on any given occasion and/or ≥8 drinks/week for women, and ≥5 drinks on any given occasion and/or ≥15 drinks/week for men)
* Use of dietary supplements that contain probiotics or phages
* Actively trying to lose weight
* Participation in other research studies that would interfere with study endpoints or compliance
* Unable or unwilling to consume capsules, provide stool or blood samples, track bowel movements and symptoms, and attend scheduled clinic visits

Where it's running

• Colorado State University
  Fort Collins, Colorado, United States Recruiting

Study contacts

• Principal investigator: Tiffany Weir, PhD — Colorado State University
• Study coordinator: Tiffany Weir, PhD
• Email: tiffany.weir@colostate.edu
• Phone: 970-215-7571

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.