PF-07328948 for adults with heart failure (BRANCH-HF).

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

BRANCH-HF is a phase 2, randomized, placebo-controlled trial testing three dose levels of PF-07328948 versus placebo in adults with heart failure and left ventricular ejection fraction greater than 40%. Participants will take the study medicine or placebo once daily for 36 weeks while continuing standard-of-care treatment including SGLT2 inhibitors. The study follows participants for about 48 weeks with 15 visits total, roughly 10 in-person clinic visits and up to 5 remote contacts. Safety, tolerability, and effects on symptoms and functional capacity will be measured to help define optimal dosing.

Why it matters

Who can join: the full rules

This study is seeking participants who are:

Key Inclusion Criteria include:

* aged 18 years to \< 80 years
* clinically confirmed to have a diagnosis of heart failure for at least 3 months
* New York Heart Association Class II-IV symptoms
* left ventricular ejection fraction greater than 40%
* Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score \< 85
* Six-minute walking distance greater than 75 meters

Key Exclusion Criteria include:

* Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body.
* Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.
* History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes
* Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor

Where it's running

• Comprehensive Cardiovascular Care
  Santa Maria, California, United States Recruiting
• FOMAT Medical Research
  Santa Maria, California, United States Recruiting
• Jacksonville Center for Clinical Research
  Jacksonville, Florida, United States Recruiting
• Infinite Clinical Research
  Miami, Florida, United States Recruiting
• Flourish Research Acquisition, LLC dba Flourish Research - North Miami
  Miami, Florida, United States Recruiting
• Amavita Research Services
  North Miami Beach, Florida, United States Recruiting

+100 more sites. See ClinicalTrials.gov for the full list.

Study contacts

• Study coordinator: Pfizer CT.gov Call Center
• Email: ClinicalTrials.gov_Inquiries@pfizer.com
• Phone: 1-800-718-1021

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.