Personalized treatment for chronic cough caused by extraesophageal reflux
Individualized Diagnosis and Treatment of Extraesophageal Reflux in Patients With Chronic Cough
This study is testing a personalized approach to treat chronic cough caused by extraesophageal reflux in patients to see if it can improve their quality of life.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 150 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | University Hospital Ostrava Academic / other |
| Locations | 1 site (Ostrava, Moravian-Silesian Region) |
| Trial ID | NCT04984304 on ClinicalTrials.gov |
What this trial studies
This study focuses on diagnosing and treating extraesophageal reflux (EER) in patients suffering from chronic cough, which can significantly impair quality of life. It aims to accurately identify EER as a primary or contributing factor to chronic cough, particularly in patients with or without allergic conditions. Participants will undergo a thorough assessment, including anamnestic questionnaires and allergology examinations, to determine the severity of their symptoms. Based on the findings, patients will be categorized for treatment, with mild cases receiving lifestyle and dietary modifications, while severe cases will receive individualized treatment plans.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-80 with chronic cough lasting three months or longer.
Not a fit: Patients with certain chronic lung diseases, head and neck cancers, or those on specific medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more effective management of chronic cough, improving patients' quality of life.
How similar studies have performed: While the specific approach of this study may be novel, similar studies have shown promise in addressing chronic cough through targeted interventions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * age 18-80 years * patients with chronic cough (cough that lasts 3 months or longer) * consent with participation in the study Exclusion Criteria: * patients using ACE inhibitors or Angiotensin II receptor blockers * patients with head and neck cancer * patients after radiotherapy in the head and neck area * patients with airway or lung cancer * patients with chronic lung disease except for bronchial asthma (COPD, interstitial lung disease, bronchiectasis, respiratory bronchiolitis) * patients with chronic rhinosinusitis
Where this trial is running
Ostrava, Moravian-Silesian Region
- University Hospital Ostrava — Ostrava, Moravian-Silesian Region, Czechia (Recruiting)
Study contacts
- Principal investigator: Viktória Hránková, MD,PhD,FESO — University Hospital Ostrava
- Study coordinator: Jiří Hynčica
- Email: jiri.hyncica@fno.cz
- Phone: 0042059737
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.