Personalized Metacognitive Training for Psychosis
Official title: Towards a Personalized Medicine Approach to Psychological Treatment for Psychosis
Run by University Hospital, Strasbourg, France · NCT07146802 · Data updated 2026-11-12
A randomized trial tests whether personalized metacognitive training helps people with psychosis better than standard MCT.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 51 (estimated) |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Status | Recruiting |
| Started | April 3, 2026 |
| Main results expected | April 1, 2027 |
| Study ends | April 1, 2027 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT07146802 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18-65 with a DSM-5 schizophrenia spectrum disorder, positive symptoms, stable medication status, and consent able to participate.
✕Probably not a fit
Individuals with recent MCT exposure, significant risk to self or others, or unstable medical/psychiatric status may see little or no benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study compares classical Metacognitive Training (MCT) with a personalized version (P-MCT) for adults with schizophrenia spectrum disorders. It uses machine learning to tailor the training approach and measures effects on clinical symptoms, cognition, and quality of life. Participants are inpatients or outpatients with stable conditions and active positive symptoms, randomized to either standard MCT or P-MCT. The trial focuses on improving overall functioning through targeted cognitive-bias modification. Outcomes will inform whether personalization enhances benefit beyond standard MCT.
Why it matters
Potential benefit: If successful, participants may experience greater improvements in symptoms, thinking patterns, and daily functioning due to a tailored intervention.
How similar studies have gone: Previous MCT approaches have shown benefits; adding personalization via machine learning is a novel aspect that requires further demonstration of impact.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults, 18 - 65 years of age. * Patient affiliated to health insurance * Inpatients and outpatients with DSM-5 diagnosis of schizophrenia spectrum disorder. * Presence of positive symptoms at inclusion (PANSS delusions, suspiciousness or grandiosity ≥3). * Stable condition with no expected changes in medication or symptoms during the last 3 months (information from clinical services, note that stable condition includes lack of suicidality). * Patient providing informed consent. Exclusion Criteria: * Having received MCT in the previous year. * Neurological disorder, or severe medical condition other than psychosis * A score above 5 in the "Hostility" and the "Suspiciousness" items of the PANSS Positive subscale (to preserve group dynamics). * Patient considered by his psychiatrist to be at serious risk of harm to self or others (e.g. previous aggressive or suicidal behaviors) * Patient in an exclusion period defined by another research protocol * Patient involved in another Investigational Medicinal Product trial * Patient under guardianship (i.e. French "tutelle") * Patients deprived of freedom because of a judicial measure.
Where it's running
-
Service de psychiatrie
Strasbourg, France Recruiting
Study contacts
- Study coordinator: Fabrice BERNA, MD
- Email: fabrice.berna@chru-strasbourg.fr
- Phone: 33 (0)3 88 11 64 62
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.