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Clinical trial Recruiting at 2 sites Phase1; Phase2 Interventional Ages 20 to 50 Women only

Personalized IVF medication planning using the Opt‑IVF decision tool

Official title: An Advanced Decision Support Tool for Personalized Medicine for IVF Using Modeling and Optimization for PPOS

Run by Stochastic Research Technologies LLC · NCT07148999 · Data updated 2026-11-12

This trial will test whether a computer tool called Opt‑IVF can choose better, personalized ovarian stimulation drug doses for women having IVF than the current standard dosing.

Quick facts

PhasePhase1; Phase2
Study typeInterventional
Ages20 Years to 50 Years
SexWomen only
Enrollment200 (estimated)
SponsorStochastic Research Technologies LLC
Industry-sponsored
Locations2 sites (Houston, Texas and 1 other locations)
StatusRecruiting
StartedSeptember 23, 2025
Main results expectedFebruary 15, 2026
Study endsFebruary 15, 2026
Registry record updatedSeptember 29, 2025
Trial IDNCT07148999 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Women with infertility who plan to undergo their own IVF cycles (no donor cycles) and are willing to be treated at the participating clinics are the intended participants.

Probably not a fit

People who are not undergoing IVF, who will use donor eggs, whose cycles are converted to IUI, or male patients will not be eligible and would not benefit from this intervention.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a randomized, two‑arm trial enrolling just over 100 infertile women undergoing IVF at two Texas clinics. One group will receive superovulation medication doses predicted by the Opt‑IVF decision support tool, and the other group will receive the current standard dosing. Outcomes compared include number and percentage of mature follicles retrieved, total FSH and HMG dosages used, number of monitoring/testing days, total M2s, number of embryos, Grade A embryos, and Grade A blastocysts. The Opt‑IVF tool is investigational and not approved by any regulatory body, and all treatment will be provided at the participating sites as part of the research protocol.

Why it matters

Potential benefit: If successful, the tool could reduce medication use and monitoring days while increasing the number and quality of mature eggs and embryos for patients.

How similar studies have gone: Algorithmic and model‑based dosing approaches for ovarian stimulation have shown some promise in small or preliminary studies, but this particular Opt‑IVF approach is relatively novel and not yet widely validated.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* infertile women

Exclusion Criteria:

All female patients who will not undergo IVF or whose cycles will be converted to IUI. Male patients will not be enrolled in this study. No donor cycles.

Where it's running

  • Positivf Fertility
    Houston, Texas, United States     Recruiting
  • Positivf Fertility
    San Antonio, Texas, United States     Recruiting

Study contacts

  • Principal investigator: Paul Magarelli, M.D., Ph.D. — IVF Academy USA
  • Study coordinator: Urmila Diwekar, Ph.D.
  • Email: urmila@vri-custom.org
  • Phone: 6308863047

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.