Personalized exercise therapy for improving insulin sensitivity in overweight individuals
Individual Responses in Insulin Sensitivity to Different Exercise Modalities in Persons With Overweight: a Randomized Cross-over Pilot Study
NA · Rigshospitalet, Denmark · NCT05718089
This study is testing a personalized exercise program to see if different types of workouts can help overweight people improve their insulin sensitivity.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 25 (estimated) |
| Ages | 40 Years to 90 Years |
| Sex | All |
| Sponsor | Rigshospitalet, Denmark (other) |
| Locations | 1 site (Copenhagen, Østerbro) |
| Trial ID | NCT05718089 on ClinicalTrials.gov |
What this trial studies
This pilot study aims to design a precision exercise therapy program tailored to physically inactive individuals with overweight, focusing on how different exercise modalities can enhance insulin sensitivity based on individual biology and context. Twenty-five participants will engage in three types of exercise: continuous aerobic, high-intensity interval training, and resistance training, with insulin sensitivity assessed after each modality. The study will evaluate the duration of insulin sensitivity improvements and the variability of responses to different exercise types over a seven-week period. This foundational research is crucial for developing effective precision therapeutics in exercise.
Who should consider this trial
Good fit: Ideal candidates are individuals over 40 years old with a BMI greater than 25 who engage in less than 1.5 hours of structured physical activity per week.
Not a fit: Patients with uncontrolled hypertension, endocrine disorders, or those on glucose-lowering medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to personalized exercise recommendations that significantly improve insulin sensitivity in overweight individuals.
How similar studies have performed: While similar approaches to personalized exercise interventions exist, this specific precision exercise therapy concept is relatively novel and untested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * BMI\>25 * Age\> 40 years * Inactivity, defined as \< 1,5 hours of structured physical activity pr. week at moderate intensity and cycling \< 30 minutes/5 km pr. day at moderate intensity (moderate intensity = out of breath but able to speak) Exclusion Criteria: * • HbA1c\>53 mmol/mol * Uncontrolled hypertension * Uncontrolled hyperlipidemia, * Known hyperthyroid disease * Endocrine disorders causing obesity * Known autoimmune disease * Unstable cardiovascular disease * Glucose lowering medications except for low dose metformin (=\<1000 mg/day) * Current treatment with anti-inflammatory medication, unless pain killers without prescription * No participation in other research intervention studies * Pregnancy/considering pregnancy within the study period * Conditions countering exercise
Where this trial is running
Copenhagen, Østerbro
- Center for Aktiv Sundhed - Rigshospitalet, Denmark (CFAS) — Copenhagen, Østerbro, Denmark (RECRUITING)
Study contacts
- Principal investigator: Mathias Ried-Larsen, Ph D — Center for Physical Activity Research, Rigshospitalet
- Study coordinator: Mathias Ried-Larsen, Ph D
- Email: mathias.ried-larsen@regionh.dk
- Phone: +4535457641
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Overweight, Healthy