Personalized brain stimulation treatment for PTSD in veterans and first responders

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of EEG-based Transcranial Magnetic Stimulation (eTMS) in treating Post-Traumatic Stress Disorder (PTSD) among U.S. military veterans and first responders. Participants will undergo EEG recordings to tailor the eTMS treatment, followed by 15 in-office sessions over 21-28 days. The study aims to recruit 110 individuals and will assess the reduction of PTSD symptoms using the PTSD Checklist for DSM-5 (PCL-5). It is a randomized, sham-controlled trial designed to ensure the reliability of results.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Willing and able to consent to participate in the study via signed Informed Consent
* Age 22 - 65 years
* Diagnosis of PTSD according to DSM-5 criteria via the Clinician-Administered PTSD Scale (CAPS).
* Onset of symptoms meeting the DSM-5 criteria for PTSD symptoms persisting for a minimum of 6 months prior to the Screening Visit
* Veterans Administration PCL-5 cut point score of 31 or above
* Positive identification as either a Veteran, or First Responder (e.g., emergency medical service provider, firefighter, or any other emergency response personnel)

Exclusion Criteria:

* Uncontrolled medical, psychological or neurological condition
* Pregnant, or female unwilling to use effective birth control during the course of the trial
* Metal objects in the head
* Past exposure to metal fragments, permanent piercings, and/or other possible metal sources in the head and neck
* Current participation in any interventional research protocol
* History of any type of Electroconvulsive Therapy (ECT) or repetitive Transcranial Magnetic Stimulation (rTMS)
* History of stroke or intracranial lesion or increased intracranial pressure
* History of epilepsy of seizure
* Family history of epilepsy or seizure in 1st degree relative
* An elevated risk of suicide or violence to others

Where it's running

• Wright State University
  Dayton, Ohio, United States Recruiting
• D2 Human Performance Center
  Pickerington, Ohio, United States Recruiting

Study contacts

• Principal investigator: Bill Phillips, PhD — Wave Neuroscience, Inc.
• Study coordinator: Matthew Sherwood, PhD
• Email: msherwood@etmsfda.com
• Phone: 937-775-2342

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.