Perioperative complications after neoadjuvant radiotherapy for colorectal cancer
Official title: Effect of Neoadjuvant Radiotherapy on the Incidence of Perioperative Complications After Radical Surgical Treatment of Colorectal Cancer
Run by Oncology Institute of Vojvodina · NCT07249333 · Data updated 2026-11-12
This study will see if adults with colorectal cancer who receive preoperative (neoadjuvant) radiotherapy have different rates of perioperative complications after radical surgery compared with those who do not.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Oncology Institute of Vojvodina Government |
| Drugs / interventions | radiation |
| Locations | 1 site (Kamenitz, Vojvodina) |
| Status | Recruiting |
| Started | June 18, 2024 |
| Main results expected | June 2026 |
| Study ends | June 2026 |
| Registry record updated | November 25, 2025 |
| Trial ID | NCT07249333 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults over 18 years old with colorectal cancer, Clinical Frailty Scale 2–4, undergoing radical (curative-intent) colorectal surgery at the Oncology Institute of Vojvodina.
✕Probably not a fit
Patients undergoing palliative colorectal surgery, children, or those with Clinical Frailty Scale outside the 2–4 range would not be included and are unlikely to benefit from these results.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This retrospective observational study uses medical records from the Oncology Institute of Vojvodina to compare patients who received neoadjuvant radiotherapy with those who did not. Researchers will extract demographic data, comorbidities, Clinical Frailty Scale, length of hospital and intensive care stay, and perioperative complications from the institute's information system. The primary analysis compares the incidence and severity of perioperative complications following radical colorectal cancer surgery between the two groups, with subgroup analyses by frailty and comorbidity burden. Adults undergoing curative-intent colorectal resection with Clinical Frailty Scale 2–4 are included while palliative surgeries are excluded.
Why it matters
Potential benefit: If successful, the results could help clinicians and patients weigh the benefits of tumor downstaging against the risk of increased perioperative complications and improve perioperative planning.
How similar studies have gone: Previous studies have reported mixed results—some have found increased perioperative morbidity after neoadjuvant radiotherapy (particularly when combined with chemotherapy), while others showed little or no difference, so this question remains unsettled.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (over 18 years of age) * Clinical Frailty Scale 2, 3 or 4 status * Patients undergoing radical surgical treatment of colorectal cancer Exclusion Criteria: * Patients undergoing palliative surgical treatment of colorectal cancer
Where it's running
-
Oncology Institute of Vojvodina
Kamenitz, Vojvodina, Serbia Recruiting
Study contacts
- Study coordinator: Nora Mihalek, MD
- Email: noramihalek@gmail.com
- Phone: +381 62 343 159
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.