Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Peer support to improve treatment for polysubstance addiction

Official title: Peer-Delivered, Behavioral Activation Intervention to Improve Polysubstance Use and Retention in Mobile Telemedicine OUD Treatment in an Underserved, Rural Area

Run by University of Maryland, College Park · NCT05973838 · Data updated 2026-11-12

This study tests whether a peer support program can help people in rural areas stick to their medication for opioid use and reduce their use of other substances.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment160 (estimated)
SponsorUniversity of Maryland, College Park
Academic / other
Locations4 sites (Washington D.C., District of Columbia and 3 other locations)
StatusRecruiting
StartedJune 15, 2023
Main results expectedJuly 1, 2027
Study endsSeptember 1, 2027
Registry record updatedApril 27, 2026
Trial IDNCT05973838 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who are receiving treatment for opioid use disorder and have a history of polysubstance use.

Probably not a fit

Patients with active, unstable psychiatric symptoms or those unable to provide informed consent in English may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of a peer-led behavioral intervention aimed at enhancing adherence to medication for opioid use disorder (MOUD) and reducing polysubstance use among patients in underserved rural areas. The intervention, known as Peer Activate, is based on behavioral activation and is implemented by trained peer recovery specialists. Conducted as a randomized controlled trial, the study compares the outcomes of Peer Activate against standard treatment over a twelve-month period. The initiative addresses the challenges of treatment retention and polysubstance use exacerbated by limited access to care in rural communities.

Why it matters

Potential benefit: If successful, this intervention could significantly improve treatment retention and reduce substance use among patients with opioid use disorder.

How similar studies have gone: Previous studies have shown promising results for peer-led interventions in improving treatment adherence and outcomes for substance use disorders, suggesting a potential for success in this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

Patient participants in the RCT must be 18 or older; receive OUD treatment as part of the telemedicine program; and exhibit polysubstance use within the past three-months (i.e., use of one or more non-prescribed substances (excluding opioids and/or tobacco) by urine toxicology or self-report.

Exclusion Criteria:

* Demonstrating active, unstable or untreated psychiatric symptoms, including mania and/or psychosis that would interfere with study participation
* Inability to understand the study and provide informed consent in English

Where it's running

  • Caroline County Behavioral Health
    Denton, Maryland, United States
    Recruiting
  • HIPS Clinic
    Washington D.C., District of Columbia, United States
    Not yet recruiting
  • University of Maryland Baltimore (UMD Drug Treatment Center)
    Baltimore, Maryland, United States
    Not yet recruiting
  • University of Maryland, College Park
    College Park, Maryland, United States
    Not yet recruiting

Study contacts

  • Principal investigator: Jessica F Magidson, PhD — University of Maryland, College Park
  • Study coordinator: Morgan S Anvari, BA
  • Email: manvari@umd.edu
  • Phone: 3014055095

Similar studies

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.