Peer-led community health program for HIV prevention in South African youth
Thetha Nami Ngithethe Nawe ("Let's Talk"): A Step-wedge cRCT of Social Mobilisation by Peer-navigators Into Community-based Sexual Health and HIV Care (Incl. PrEP) to Reduce Sexually Transmissible HIV Amongst Youth in Rural KwaZulu-Natal
This study is testing if a community program led by peers can help young people in South Africa access better HIV prevention services and reduce the spread of the virus.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 6000 (estimated) |
| Ages | 15 Years to 30 Years |
| Sex | All |
| Sponsor | Africa Health Research Institute Academic / other |
| Locations | 1 site (Somkele, KwaZulu-Natal) |
| Trial ID | NCT05405582 on ClinicalTrials.gov |
What this trial studies
This implementation trial aims to assess the impact of social mobilisation on engaging young people aged 15-30 in decentralized sexual reproductive health (SRH) services that provide tailored HIV prevention. The study employs a step-wedge cluster randomised control trial design, comparing the effectiveness of peer-led interventions with standard care in reducing the prevalence of transmissible HIV. It will also evaluate the acceptability, practicability, and cost-effectiveness of these interventions in the uMkhanyakude district of rural KwaZulu Natal. The trial will involve approximately 26,000 participants across 40 administrative areas over a period of 15 months.
Who should consider this trial
Good fit: Ideal candidates for this study are young individuals aged 15-30 residing in the uMkhanyakude district.
Not a fit: Patients outside the age range of 15-30 or those unable to provide consent will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the prevalence of HIV among young people in South Africa.
How similar studies have performed: Other studies have shown promise in using community-led approaches for HIV prevention, indicating potential success for this novel intervention.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Resident in the cluster * Any gender * Aged 15-30 * If aged 18-30 and able and willing to consent to participate * If aged 15-17, able and willing to assent and whose guardian or parent are able and willing to consent to their participation. Exclusion Criteria: * Unable or unwilling to provide consent * Aged 14 or less * aged 31 or more
Where this trial is running
Somkele, KwaZulu-Natal
- Africa Health Research Institute — Somkele, KwaZulu-Natal, South Africa (Recruiting)
Study contacts
- Study coordinator: Maryam Shahmanesh, PhD
- Email: m.shahmanesh@ucl.ac.uk
- Phone: 07776185572
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.